Dermorphin, mu-opioid receptors agonist (ab142279)
- Datasheet
- References
Overview
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Product name
Dermorphin, mu-opioid receptors agonist -
Description
Potent and selective agonist to μ-opioid receptors -
Biological description
Potent and selective natural opioid that binds as an agonist to μ-opioid receptors. 30–40 times more potent than morphine. Antinociceptive effect. -
Purity
> 96% -
CAS Number
77614-16-5 -
Chemical structure
Properties
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Molecular weight
802.88 -
Molecular formula
C40H50N8O10 -
Sequence
YAFGYPS (Modifications: C-terminal amide; Ala-2 = D-Ala) -
PubChem identifier
5485199 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C(=O)NC(CC1=CC=CC=C1)C(=O)NCC(=O)NC(CC2=CC=C(C=C2)O)C(=O)N3CCCC3C(=O)NC(CO)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)O)N -
Source
Synthetic
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Research areas
Images
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Other - Dermorphin, mu-opioid receptors agonist (ab142279)Dermorphin (ab142279)
References
This product has been referenced in:
- Mizoguchi H et al. Dermorphin tetrapeptide analogs as potent and long-lasting analgesics with pharmacological profiles distinct from morphine. Peptides 32:421-7 (2011). Read more (PubMed: 21126548) »
- Vandormael B et al. Superpotent [Dmt¹] dermorphin tetrapeptides containing the 4-aminotetrahydro-2-benzazepin-3-one scaffold with mixed µ/d opioid receptor agonistic properties. J Med Chem 54:7848-59 (2011). Read more (PubMed: 21978284) »
- Vandormael B et al. Asymmetric synthesis and conformational analysis by NMR spectroscopy and MD of Aba- and a-MeAba-containing dermorphin analogues. ChemMedChem 6:2035-47 (2011). Read more (PubMed: 21990068) »
