Desformylflustrabromine hydrochloride, alpha4beta2 modulator (ab142815)

Overview

  • Product name

    Desformylflustrabromine hydrochloride, alpha4beta2 modulator
  • Description

    Selective positive allosteric α4β2 modulator
  • Biological description

    Selective positive allosteric nAChR α4β2 modulator (Ki = 3400 nM). Increases whole cell current when co-applied with effective concentrations of ACh. Anti-addictive effects in vivo.
  • Purity

    > 98%
  • CAS Number

    951322-11-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    6-Bromo-2-(1,1-dimethyl-2-propen-1-yl)-N-methyl-1H-indole-3-ethanamine hydrochloride
  • Molecular weight

    357.72
  • Molecular formula

    C16H21BrN2.HCl
  • PubChem identifier

    56675778
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    Cl.C=CC(C)(C)c2nc1cc(Br)ccc1c2CCNC
  • Source

    Synthetic

References

This product has been referenced in:

  • German N  et al. Deconstruction of the a4ß2 nicotinic acetylcholine receptor positive allosteric modulator desformylflustrabromine. J Med Chem 54:7259-67 (2011). Read more (PubMed: 21905680) »
  • Weltzin MM & Schulte MK Pharmacological characterization of the allosteric modulator desformylflustrabromine and its interaction with alpha4beta2 neuronal nicotinic acetylcholine receptor orthosteric ligands. J Pharmacol Exp Ther 334:917-26 (2010). Read more (PubMed: 20516140) »
  • Kim JS  et al. Synthesis of desformylflustrabromine and its evaluation as an alpha4beta2 and alpha7 nACh receptor modulator. Bioorg Med Chem Lett 17:4855-60 (2007). Read more (PubMed: 17604168) »

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