Overview

  • Product name

    Anti-Desmocollin 2 antibody [7G6] - BSA and Azide free
    See all Desmocollin 2 primary antibodies
  • Description

    Mouse monoclonal [7G6] to Desmocollin 2 - BSA and Azide free
  • Host species

    Mouse
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant fragment within Human Desmocollin 2 (extracellular). The exact sequence is proprietary.
    Database link: Q02487

  • Positive control

    • IHC-P: Human skin tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab218849 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 1 - 2 µg/ml. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

Target

  • Function

    Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
  • Tissue specificity

    Expressed in epithelia, myocardium and lymph nodes.
  • Involvement in disease

    Defects in DSC2 are the cause of familial arrhythmogenic right ventricular dysplasia type 11 (ARVD11) [MIM:610476]; also known as arrhythmogenic right ventricular cardiomyopathy 11 (ARVC11). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.
  • Sequence similarities

    Contains 5 cadherin domains.
  • Domain

    Calcium may be bound by the cadherin-like repeats.
  • Cellular localization

    Cell membrane. Cell junction > desmosome.
  • Information by UniProt
  • Database links

  • Alternative names

    • ARVD11 antibody
    • Cadherin family member 2 antibody
    • CDHF2 antibody
    • Desmocollin 3 antibody
    • Desmocollin-2 antibody
    • Desmocollin-3 antibody
    • Desmocollin2 antibody
    • Desmosomal glycoprotein II and III antibody
    • Desmosomal glycoprotein II antibody
    • Desmosomal glycoprotein II/III antibody
    • Desmosomal glycoprotein III antibody
    • DG2 antibody
    • DGII/III antibody
    • DKFZp686I11137 antibody
    • DSC 2 antibody
    • DSC2 antibody
    • DSC2_HUMAN antibody
    • DSC3 antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed paraffin-embedded human skin tissue sections labeling Desmocollin 2 with ab218849 at 2 µg/mL.

References

ab218849 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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