Key features and details
- Rabbit polyclonal to Desmocollin 2
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Desmocollin 2 antibody
See all Desmocollin 2 primary antibodies
DescriptionRabbit polyclonal to Desmocollin 2
Tested applicationsSuitable for: WB, IHC-Pmore details
Species reactivityReacts with: Human
Recombinant fragment, corresponding to a region within amino acids 480-676 of Human Desmocollin 2 isoform 2A and 2B (Uniprot ID = Q02487).
- WB: A431 cells. IHC-P: OVCAR3 xenograft.
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferpH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine)
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab95967 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/3000. Predicted molecular weight: 94 kDa.|
|IHC-P||1/100 - 1/1000.|
FunctionComponent of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
Tissue specificityExpressed in epithelia, myocardium and lymph nodes.
Involvement in diseaseDefects in DSC2 are the cause of familial arrhythmogenic right ventricular dysplasia type 11 (ARVD11) [MIM:610476]; also known as arrhythmogenic right ventricular cardiomyopathy 11 (ARVC11). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.
Sequence similaritiesContains 5 cadherin domains.
DomainCalcium may be bound by the cadherin-like repeats.
Cellular localizationCell membrane. Cell junction > desmosome.
- Information by UniProt
- ARVD11 antibody
- Cadherin family member 2 antibody
- CDHF2 antibody
ab95967 has been referenced in 2 publications.
- Gumber S et al. Immunohistological characterization of intercellular junction proteins in rhesus macaque intestine. Exp Toxicol Pathol 66:437-44 (2014). PubMed: 25153024
- Resnik N et al. Desmosome assembly and cell-cell adhesion are membrane raft-dependent processes. J Biol Chem 286:1499-507 (2011). WB ; Dog . PubMed: 21071449