Anti-Desmoglein 1/DSG1 antibody - C-terminal (ab227925)
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Overview
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Product name
Anti-Desmoglein 1/DSG1 antibody - C-terminal
See all Desmoglein 1/DSG1 primary antibodies -
Description
Rabbit polyclonal to Desmoglein 1/DSG1 - C-terminal -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide within Human Desmoglein 1/DSG1 (C terminal). The exact sequence is proprietary. Conjugated to a protein carrier.
Database link: Q02413 -
Positive control
- WB: A-375 whole cell extract.
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General notes
This product was previously labelled as Desmoglein 1
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.00
Preservative: 0.025% Proclin
Constituents: PBS, 20% Glycerol -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
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Related Products
Applications
Our Abpromise guarantee covers the use of ab227925 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB | 1/500 - 1/3000. Predicted molecular weight: 114 kDa. |
Target
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Function
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. -
Tissue specificity
Epidermis, tongue, tonsil and esophagus. -
Involvement in disease
Defects in DSG1 are the cause of palmoplantar keratoderma striate type 1 (SPPK1) [MIM:148700]; also known as keratosis palmoplantaris striata I. SPPK1 is a dermatoligical disorder characterized by thickening of the skin on the palms and soles, and longitudinal hyperkeratotic lesions on the palms, running the length of each finger. -
Sequence similarities
Contains 4 cadherin domains. -
Domain
Calcium may be bound by the cadherin-like repeats. -
Cellular localization
Cell membrane. Cell junction > desmosome. - Information by UniProt
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Database links
- Entrez Gene: 1828 Human
- Omim: 125670 Human
- SwissProt: Q02413 Human
- Unigene: 2633 Human
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Alternative names
- Cadherin family member 4 antibody
- CDHF4 antibody
- Desmoglein-1 antibody
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Images
References
ab227925 has not yet been referenced specifically in any publications.