Overview

  • Product name

    Anti-Desmoglein 1/DSG1 antibody - C-terminal
    See all Desmoglein 1/DSG1 primary antibodies
  • Description

    Rabbit polyclonal to Desmoglein 1/DSG1 - C-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human Desmoglein 1/DSG1 (C terminal). The exact sequence is proprietary. Conjugated to a protein carrier.
    Database link: Q02413

  • Positive control

    • WB: A-375 whole cell extract.
  • General notes

     This product was previously labelled as Desmoglein 1

     

Properties

Applications

Our Abpromise guarantee covers the use of ab227925 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 114 kDa.

Target

  • Function

    Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
  • Tissue specificity

    Epidermis, tongue, tonsil and esophagus.
  • Involvement in disease

    Defects in DSG1 are the cause of palmoplantar keratoderma striate type 1 (SPPK1) [MIM:148700]; also known as keratosis palmoplantaris striata I. SPPK1 is a dermatoligical disorder characterized by thickening of the skin on the palms and soles, and longitudinal hyperkeratotic lesions on the palms, running the length of each finger.
  • Sequence similarities

    Contains 4 cadherin domains.
  • Domain

    Calcium may be bound by the cadherin-like repeats.
  • Cellular localization

    Cell membrane. Cell junction > desmosome.
  • Information by UniProt
  • Database links

  • Alternative names

    • Cadherin family member 4 antibody
    • CDHF4 antibody
    • Desmoglein-1 antibody
    • Desmosomal glycoprotein 1 antibody
    • DG1 antibody
    • DGI antibody
    • DSG antibody
    • DSG1 antibody
    • DSG1_HUMAN antibody
    • EPKHE antibody
    • EPKHIA antibody
    • Pemphigus foliaceus antigen antibody
    • PPKS1 antibody
    • SPPK1 antibody
    see all

Images

  • Anti-Desmoglein 1/DSG1 antibody - C-terminal (ab227925) at 1/500 dilution + A-375 (human malignant melanoma cell line) whole cell extract at 30 µg

    Predicted band size: 114 kDa



    5% SDS-PAGE gel.

References

ab227925 has not yet been referenced specifically in any publications.

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