Anti-Desmoglein 1/DSG1 antibody - C-terminal (ab227925)

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Overview

  • Product name

    Anti-Desmoglein 1/DSG1 antibody - C-terminal
    See all Desmoglein 1/DSG1 primary antibodies

  • Description

    Rabbit polyclonal to Desmoglein 1/DSG1 - C-terminal

  • Host species

    Rabbit

  • Tested applications

    Suitable for: WBmore details

  • Species reactivity

    Reacts with: Human

  • Immunogen

    Synthetic peptide within Human Desmoglein 1/DSG1 (C terminal). The exact sequence is proprietary. Conjugated to a protein carrier.
    Database link: Q02413

  • Positive control

    • WB: A-375 whole cell extract.

  • General notes

     This product was previously labelled as Desmoglein 1

     

Properties

Applications

Our Abpromise guarantee covers the use of ab227925 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 114 kDa.

Target

  • Function

    Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

  • Tissue specificity

    Epidermis, tongue, tonsil and esophagus.

  • Involvement in disease

    Defects in DSG1 are the cause of palmoplantar keratoderma striate type 1 (SPPK1) [MIM:148700]; also known as keratosis palmoplantaris striata I. SPPK1 is a dermatoligical disorder characterized by thickening of the skin on the palms and soles, and longitudinal hyperkeratotic lesions on the palms, running the length of each finger.

  • Sequence similarities

    Contains 4 cadherin domains.

  • Domain

    Calcium may be bound by the cadherin-like repeats.

  • Cellular localization

    Cell membrane. Cell junction > desmosome.
  • Information by UniProt

  • Database links

    • Alternative names

      • Cadherin family member 4 antibody
      • CDHF4 antibody
      • Desmoglein-1 antibody
      • Desmosomal glycoprotein 1 antibody
      • DG1 antibody
      • DGI antibody
      • DSG antibody
      • DSG1 antibody
      • DSG1_HUMAN antibody
      • EPKHE antibody
      • EPKHIA antibody
      • Pemphigus foliaceus antigen antibody
      • PPKS1 antibody
      • SPPK1 antibody
      see all

    Images

    • Western blot - Anti-Desmoglein 1/DSG1 antibody - C-terminal (ab227925)
      Western blot - Anti-Desmoglein 1/DSG1 antibody - C-terminal (ab227925)
      Anti-Desmoglein 1/DSG1 antibody - C-terminal (ab227925) at 1/500 dilution + A-375 (human malignant melanoma cell line) whole cell extract at 30 µg

      Predicted band size: 114 kDa



      5% SDS-PAGE gel.

    References

    ab227925 has not yet been referenced specifically in any publications.

    Publishing research using ab227925? Please let us know so that we can cite the reference in this datasheet.

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