Overview

  • Product name

    Anti-Desmoglein 1/DSG1 antibody [DSG1/1733]
    See all Desmoglein 1/DSG1 primary antibodies
  • Description

    Mouse monoclonal [DSG1/1733] to Desmoglein 1/DSG1
  • Host species

    Mouse
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment within Human Desmoglein 1/DSG1 aa 570-1049 (intracellular). The exact sequence is proprietary.
    Database link: Q02413

  • Positive control

    • IHC-P: Human skin tissue.
  • General notes

     This product was previously labelled as Desmoglein 1

     

Properties

Applications

Our Abpromise guarantee covers the use of ab218378 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 0.5 - 1 µg/ml. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

Target

  • Function

    Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
  • Tissue specificity

    Epidermis, tongue, tonsil and esophagus.
  • Involvement in disease

    Defects in DSG1 are the cause of palmoplantar keratoderma striate type 1 (SPPK1) [MIM:148700]; also known as keratosis palmoplantaris striata I. SPPK1 is a dermatoligical disorder characterized by thickening of the skin on the palms and soles, and longitudinal hyperkeratotic lesions on the palms, running the length of each finger.
  • Sequence similarities

    Contains 4 cadherin domains.
  • Domain

    Calcium may be bound by the cadherin-like repeats.
  • Cellular localization

    Cell membrane. Cell junction > desmosome.
  • Information by UniProt
  • Database links

  • Alternative names

    • Cadherin family member 4 antibody
    • CDHF4 antibody
    • Desmoglein-1 antibody
    • Desmosomal glycoprotein 1 antibody
    • DG1 antibody
    • DGI antibody
    • DSG antibody
    • DSG1 antibody
    • DSG1_HUMAN antibody
    • EPKHE antibody
    • EPKHIA antibody
    • Pemphigus foliaceus antigen antibody
    • PPKS1 antibody
    • SPPK1 antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed paraffin-embedded human skin tissue sections labeling Desmoglein 1/DSG1 with ab218378 at 1 µg/mL.

References

ab218378 has not yet been referenced specifically in any publications.

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