Overview

  • Product name

    Anti-Desmoglein 1/DSG1 antibody [EP6765]
    See all Desmoglein 1/DSG1 primary antibodies
  • Description

    Rabbit monoclonal [EP6765] to Desmoglein 1/DSG1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
    Unsuitable for: IHC-P or IP
  • Species reactivity

    Reacts with: Human
  • Immunogen

    corresponding to Human Desmoglein 1/DSG1 aa 200-300.
    Database link: Q02413

  • Positive control

    • Human fetal skin lysate
  • General notes

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

     This product was previously labelled as Desmoglein 1

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

Properties

Applications

Our Abpromise guarantee covers the use of ab133662 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/100. Predicted molecular weight: 114 kDa.
  • Application notes
    Is unsuitable for IHC-P or IP.
  • Target

    • Function

      Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
    • Tissue specificity

      Epidermis, tongue, tonsil and esophagus.
    • Involvement in disease

      Defects in DSG1 are the cause of palmoplantar keratoderma striate type 1 (SPPK1) [MIM:148700]; also known as keratosis palmoplantaris striata I. SPPK1 is a dermatoligical disorder characterized by thickening of the skin on the palms and soles, and longitudinal hyperkeratotic lesions on the palms, running the length of each finger.
    • Sequence similarities

      Contains 4 cadherin domains.
    • Domain

      Calcium may be bound by the cadherin-like repeats.
    • Cellular localization

      Cell membrane. Cell junction > desmosome.
    • Information by UniProt
    • Database links

    • Alternative names

      • Cadherin family member 4 antibody
      • CDHF4 antibody
      • Desmoglein-1 antibody
      • Desmosomal glycoprotein 1 antibody
      • DG1 antibody
      • DGI antibody
      • DSG antibody
      • DSG1 antibody
      • DSG1_HUMAN antibody
      • EPKHE antibody
      • EPKHIA antibody
      • Pemphigus foliaceus antigen antibody
      • PPKS1 antibody
      • SPPK1 antibody
      see all

    Images

    • Anti-Desmoglein 1/DSG1 antibody [EP6765] (ab133662) at 1/1000 dilution + Human fetal skin lysate at 10 µg

      Secondary
      HRP conjugated Goat anti-Rabbit at 1/2000 dilution

      Predicted band size: 114 kDa

    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD

    References

    This product has been referenced in:

    • Klymenko T  et al. RNASeq analysis of differentiated keratinocytes reveals a massive response to late events during human papillomavirus type 16 infection, including loss of epithelial barrier function. J Virol N/A:N/A (2017). Read more (PubMed: 29021401) »
    See 1 Publication for this product

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab133662.
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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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