Overview

  • Product name

    Anti-Desmoglein 3/PVA antibody [DSG3/1535]
    See all Desmoglein 3/PVA primary antibodies
  • Description

    Mouse monoclonal [DSG3/1535] to Desmoglein 3/PVA
  • Host species

    Mouse
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment within Human Desmoglein 3/PVA (extracellular). The exact sequence is proprietary.
    Database link: P32926

  • Positive control

    • IHC-P: Human skin tissue. Human lung squamous cell carcinoma.
  • General notes

    Previously labelled as Desmoglein 3. 

Properties

Applications

Our Abpromise guarantee covers the use of ab218380 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 1 - 2 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

(for 30 minutes at RT)

Target

  • Function

    Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
  • Tissue specificity

    Epidermis, tongue, tonsil, esophagus and carcinomas.
  • Sequence similarities

    Contains 4 cadherin domains.
  • Domain

    Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
  • Cellular localization

    Cell membrane. Cell junction > desmosome.
  • Information by UniProt
  • Database links

  • Alternative names

    • 130 kD pemphigus vulgaris antigen antibody
    • 130 kDa pemphigus vulgaris antigen antibody
    • Balding antibody
    • Cadherin family member 6 antibody
    • CDHF 6 antibody
    • CDHF6 antibody
    • Desmoglein 3 antibody
    • Desmoglein 3 precursor antibody
    • Desmoglein-3 antibody
    • Desmoglein3 antibody
    • DKFZp686P23184 antibody
    • DSG 3 antibody
    • DSG3 antibody
    • DSG3_HUMAN antibody
    • Pemphigus vulgaris antigen antibody
    • PVA antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded human lung squamous cell carcinoma tissue labeling Desmoglein 3/PVA with ab218380 at 2 µg/mL.

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded human skin tissue labeling Desmoglein 3/PVA with ab218380 at 2 µg/mL.

References

ab218380 has not yet been referenced specifically in any publications.

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