Overview

  • Product name

    Anti-Desmoglein 3/PVA antibody [EPR7420]
    See all Desmoglein 3/PVA primary antibodies
  • Description

    Rabbit monoclonal [EPR7420] to Desmoglein 3/PVA
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC,IHC-P or IP
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human Desmoglein 3/PVA aa 900-1000. The exact sequence is proprietary.

  • Positive control

    • Human tonsil and A431 lysates.
  • General notes

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

     

    Previously labelled as Desmoglein 3. 

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab128927 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Detects a band of approximately 130 kDa (predicted molecular weight: 108 kDa).
  • Application notes
    Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
  • Target

    • Function

      Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
    • Tissue specificity

      Epidermis, tongue, tonsil, esophagus and carcinomas.
    • Sequence similarities

      Contains 4 cadherin domains.
    • Domain

      Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
    • Cellular localization

      Cell membrane. Cell junction > desmosome.
    • Information by UniProt
    • Database links

    • Alternative names

      • 130 kD pemphigus vulgaris antigen antibody
      • 130 kDa pemphigus vulgaris antigen antibody
      • Balding antibody
      • Cadherin family member 6 antibody
      • CDHF 6 antibody
      • CDHF6 antibody
      • Desmoglein 3 antibody
      • Desmoglein 3 precursor antibody
      • Desmoglein-3 antibody
      • Desmoglein3 antibody
      • DKFZp686P23184 antibody
      • DSG 3 antibody
      • DSG3 antibody
      • DSG3_HUMAN antibody
      • Pemphigus vulgaris antigen antibody
      • PVA antibody
      see all

    Images

    • All lanes : Anti-Desmoglein 3/PVA antibody [EPR7420] (ab128927) at 1/1000 dilution

      Lane 1 : Human tonsil lysate
      Lane 2 : A431 lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : Goat anti-rabbit HRP at 1/2000 dilution

      Predicted band size: 108 kDa

    References

    This product has been referenced in:

    • Gallegos LL  et al. A protein interaction map for cell-cell adhesion regulators identifies DUSP23 as a novel phosphatase for ß-catenin. Sci Rep 6:27114 (2016). Read more (PubMed: 27255161) »
    See 1 Publication for this product

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab128927.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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