Overview

  • Product name

    Anti-Desmoglein 4 antibody
    See all Desmoglein 4 primary antibodies
  • Description

    Rabbit polyclonal to Desmoglein 4
  • Host species

    Rabbit
  • Specificity

    ab192408 detects endogenous levels of Desmoglein 4 protein.
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human Desmoglein 4. The exact sequence is proprietary.
    Database link: Q86SJ6

  • Positive control

    • HEK293T, sp2/0 and H9C2 whole cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab192408 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 114 kDa.

Target

  • Relevance

    DSG4(Desmoglein 4) is a component of intercellular desmosome junctions. DSG4 is involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. DSG4 coordinates the transition from proliferation to differentiation in hair follicle keratinocytes. The essential role of desmoglein 4 in skin was established by identifying mutations in families with inherited hypotrichosis, as well as in the lanceolate hair mouse. The human desmoglein 4 gene (DSG4) demonstrates that it is composed of 16 exons spanning approximately 37 kb of 18q12 and is situated between DSG1 and DSG3. Defects in DSG4 are the cause of localized autosomal hypotrichosis (LAH). LAH is an autosomal recessive skin disorder. DSG4 is one of the target molecules recognized by autoantibodies in patients with pemphigus vulgaris. Pemphigus vulgaris is a potentially lethal skin disease in which epidermal blisters occur as the result of the loss of cell-cell adhesion.
  • Cellular localization

    Cell membrane; single pass type I membrane protein.
  • Database links

  • Alternative names

    • CDGF 13 antibody
    • CDGF13 antibody
    • CDH family member 13 antibody
    • CDHF 13 antibody
    • CDHF13 antibody
    • Desmoglein 4 antibody
    • Desmoglein4 antibody
    • DSG 4 antibody
    • DSG4 antibody
    • LAH antibody
    see all

Images

  • All lanes : Anti-Desmoglein 4 antibody (ab192408)

    Lane 1 : HEK293T whole cell lysate
    Lane 2 : sp2/0 whole cell lysate
    Lane 3 : H9C2 whole cell lysate

    Predicted band size: 114 kDa

References

ab192408 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab192408.
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