Overview

  • Product name

  • Description

    Rabbit polyclonal to Desmoplakin
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide derived from an internal domain of Human Desmoplakin.

Properties

Applications

Our Abpromise guarantee covers the use of ab106342 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/5000. Predicted molecular weight: 331 kDa.

Target

  • Relevance

    Desmosomes are the most common type of intercellular junction in vertebrate epithelial cells. They are characterized by 2 forms of interaction with other cellular structures. First, they form membrane anchorage sites for intermediate-size filaments, which are seen as electron-dense plaques evident beneath the plasma membrane. Second, a specific membrane core domain interacts with a corresponding domain of the plasma membrane of an adjacent cell, apparently mediating intercellular adhesion in a stable way. The desmosome intermediate filament complex is thought to impart tensile strength and resilience to the epithelium. Desmosomal proteins can be divided into 2 groups based on whether they fractionate with the urea-insoluble 'core' or the urea-soluble 'plaque' components. Desmoglein is, for example, a protein of the core. The main proteins of the plaque comprise the desmoplakins and plakoglobin.
  • Cellular localization

    Cell junction, desmosome. Cytoplasm, cytoskeleton.
  • Database links

  • Alternative names

    • 250/210 kDa paraneoplastic pemphigus antigen antibody
    • Desmoplakin I antibody
    • Desmoplakin II antibody
    • DP I antibody
    • DP II antibody
    • DPI antibody
    • DPII antibody
    • DSP antibody
    • KPPS2 antibody
    • PPKS2 antibody
    see all

References

This product has been referenced in:

See 1 Publication for this product

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