Desvenlafaxine succinate, SERT and NET inhibitor (ab143602)

Overview

  • Product name

    Desvenlafaxine succinate, SERT and NET inhibitor
  • Description

    Potent SERT and NET inhibitor. Venlafaxine (ab120715) derivative.
  • Biological description

    Potent SERT and NET inhibitor (Ki values are 40 and 122 nM for hSERT and hNET respectively). Venlafaxine (ab120715) derivative. Reduces visceral hypersensitivity and delays gastric emptying. Shows antidepressant effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    386750-22-7
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Dai F  et al. Desvenlafaxine succinate ameliorates visceral hypersensitivity but delays solid gastric emptying in rats. Am J Physiol Gastrointest Liver Physiol 305:G333-9 (2013). Read more (PubMed: 23764892) »
  • Tian JW  et al. Preclinical pharmacology of TP1, a novel potent triple reuptake inhibitor with antidepressant properties. Neuroscience 196:124-30 (2011). Read more (PubMed: 21925241) »
  • Deecher DC  et al. Desvenlafaxine succinate: A new serotonin and norepinephrine reuptake inhibitor. J Pharmacol Exp Ther 318:657-65 (2006). Read more (PubMed: 16675639) »

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