Overview

  • Product name

    Dexmedetomidine hydrochloride, alpha2 agonist
  • Description

    Potent, highly selective α2 agonist
  • Biological description

    Potent, highly selective α2 agonist. (Ki values are 1.08 and 1750 nM at α2 and α1 receptors, respectively). Active enantiomer of medetomidine (ab120787). Displays numerous actions including sedative, analgesic, anxiolytic, and antiulcerative properties.
  • Purity

    > 99%
  • CAS Number

    145108-58-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride
  • Molecular weight

    236.74
  • Molecular formula

    C13H16N2.HCl
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Polat B  et al. Antiulcerative effect of dexmedetomidine on indomethacin-induced gastric ulcer in rats. Pharmacol Rep 63:518-26 (2011). Read more (PubMed: 21602607) »
  • Fisher B  et al. Antinociceptive properties of intrathecal dexmedetomidine in rats. Eur J Pharmacol 192:221-5 (1991). Read more (PubMed: 1674472) »
  • Virtanen R  et al. Characterization of the selectivity, specificity and potency of medetomidine as an alpha 2-adrenoceptor agonist. Eur J Pharmacol 150:9-14 (1988). Read more (PubMed: 2900154) »

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