Overview

  • Product name

  • Description

    Rabbit polyclonal to DGAT2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-P, ICC/IFmore details
  • Species reactivity

    Reacts with: Mouse, Human
  • Immunogen

    Recombinant fragment corresponding to Human DGAT2 aa 1-66.
    Database link: Q96PD7

  • Positive control

    • WB: Mouse heart, liver, spleen, lung, kidney, brain and skeletal muscle lysates. IHC-P: Human liver and testis tissue. ICC/IF: HeLa cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab237613 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/5000.
IHC-P 1/20 - 1/200.
ICC/IF 1/50 - 1/200.

Target

  • Function

    Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation.
  • Tissue specificity

    Predominantly expressed in liver and white adipose tissue. Expressed at lower level in mammary gland, testis and peripheral blood leukocytes. Expressed in sebaceous glands of normal skin but decreased psoriatic skin.
  • Pathway

    Glycerolipid metabolism; triacylglycerol biosynthesis.
  • Sequence similarities

    Belongs to the diacylglycerol acyltransferase family.
  • Cellular localization

    Endoplasmic reticulum membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • DGAT2 antibody
    • DGAT2_HUMAN antibody
    • Diacylglycerol O acyltransferase like protein 2 antibody
    • Diacylglycerol O-acyltransferase 2 antibody
    • Diacylglycerol O-acyltransferase homolog 2 (mouse) antibody
    • Diacylglycerol O-acyltransferase homolog 2 antibody
    • Diacylglycerol O-acyltransferase-like protein 2 isoform 1 antibody
    • Diglyceride acyltransferase 2 antibody
    • DKFZp686A15125 antibody
    • GS1999full antibody
    • HMFN1045 antibody
    see all

Images

  • All lanes : Anti-DGAT2 antibody (ab237613) at 1/500 dilution

    Lane 1 : Mouse heart lysate
    Lane 2 : Mouse liver lysate
    Lane 3 : Mouse spleen lysate
    Lane 4 : Mouse lung lysate
    Lane 5 : Mouse kidney lysate
    Lane 6 : Mouse brain lysate
    Lane 7 : Mouse skeletal muscle lysate

    Secondary
    All lanes : Goat polyclonal to rabbit IgG at 1/50000 dilution
  • Paraffin-embedded human liver tissue stained for DGAT2 using ab237613 at 1/100 dilution in immunohistochemical analysis.

  • Paraffin-embedded human testis tissue stained for DGAT2 using ab237613 at 1/100 dilution in immunohistochemical analysis.

  • HeLa (Human epithelial cell line from cervix adenocarcinoma) cells stained for DGAT2 (green) using ab237613 at 1/100 dilution in ICC/IF. Secondary antibody is an Alexa-Fluor® 488-conjugated Goat Anti-Rabbit IgG (H+L).

References

This product has been referenced in:

  • Zhang X  et al. An Epistatic Interaction between Pnpla2 and Lipe Reveals New Pathways of Adipose Tissue Lipolysis. Cells 8:N/A (2019). Read more (PubMed: 31035700) »
See 1 Publication for this product

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