Overview

  • Product name

  • Description

    Rabbit polyclonal to DHCR7
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    The details of the immunogen for this antibody are not available.

  • Positive control

    • IHC-P: Human brain cortex tissue. WB: HepG2 cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab230462 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100.
WB 1/1000. Predicted molecular weight: 54 kDa.

Target

  • Relevance

    The DHCR7 gene encodes delta-7-sterol reductase (EC 1.3.1.21), the penultimate enzyme of mammalian sterol biosynthesis that converts 7-dehydrocholesterol (7-DHC) to cholesterol. This enzyme removes the C(7-8) double bond introduced by the sterol delta8-delta7 isomerases. In addition, its role in drug-induced malformations is known: inhibitors of the last step of cholesterol biosynthesis such as AY9944 and BM15766 severely impair brain development (Moebius et al., 1998 [PubMed 9465114]).[OMIM]
  • Cellular localization

    Endoplasmic reticulum membrane; Multi-pass membrane protein
  • Database links

  • Alternative names

    • 7 dehydrocholesterol reductase antibody
    • 7 DHC reductase antibody
    • Delta 7 dehydrocholesterol reductase antibody
    • Putative sterol reductase SR 2 antibody
    • SLOS antibody
    • Sterol delta 7 reductase antibody
    • Sterol Delta antibody
    see all

Images

  • Formalin-fixed, paraffin-embedded human brain cortex tissue stained for DHCR7 using ab230462 at 1/100 dilution in immunohistochemical analysis.

  • Anti-DHCR7 antibody (ab230462) at 1/1000 dilution + HepG2 (human liver hepatocellular carcinoma cell line) cell lysate at 20 µg

    Secondary
    Goat anti-rabbit IgG H&L (HRP) at 1/10000 dilution

    Predicted band size: 54 kDa

References

ab230462 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab230462.
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