Key features and details
- Rabbit polyclonal to DHX58/RLR
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Product nameAnti-DHX58/RLR antibody
See all DHX58/RLR primary antibodies
DescriptionRabbit polyclonal to DHX58/RLR
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Mouse, Rat, Human
Synthetic peptide corresponding to Human DHX58/RLR (internal sequence).
- Rat kidney tissue lysate.
Previously labelled as DHX58.
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Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C.
Storage bufferpH: 7.2
Preservative: 0.02% Sodium azide
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab67272 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionParticipates in innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, triggers a transduction cascade which results in the induction and expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). The RNA helicase domain may recognize and structurally modify viral RNA to facilitate detection by DDX58/RIG-I or by IFIH1/MDA5 whose affinity for dsRNA is lower.
Sequence similaritiesBelongs to the helicase family.
Contains 1 helicase ATP-binding domain.
Contains 1 helicase C-terminal domain.
- Information by UniProt
- D11LGP2 antibody
- D11lgp2e antibody
- DEXH (Asp Glu X His) box polypeptide 58 antibody
Lane 1 : Anti-DHX58/RLR antibody (ab67272) at 1 µg/ml
Lane 2 : Anti-DHX58/RLR antibody (ab67272) at 2 µg/ml
All lanes : Rat kidney tissue lysate
Lysates/proteins at 15 µg per lane.
All lanes : anti rabbit secondary antibody
Predicted band size: 45, 77 kDa
Observed band size: 45,77 kDa why is the actual band size different from the predicted?
There are 4 isoforms of LGP2 - 376, 678, 379, and 368 amino acids. The larger band is isoform b and the smaller one is either a, c, or d since they are similar in size.
ab67272 has not yet been referenced specifically in any publications.