Overview

  • Product name

    Dibenzoylmethane (DBM), chemopreventive agent
  • Description

    Prevents formation of tumor-inducing DNA adducts
  • Alternative names

    • BDM
  • Biological description

    Prevents formation of tumor-inducing DNA adducts. Antitumor agent. Active in vivo and in vitro.
  • Purity

    > 98%
  • CAS Number

    120-46-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1,3-Diphenylpropane-1,3-dione
  • Molecular weight

    224.25
  • Molecular formula

    C15H12O2
  • PubChem identifier

    8433
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC=C(C=C1)C(=O)CC(=O)C2=CC=CC=C2
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Sung B  et al. Cancer cell signaling pathways targeted by spice-derived nutraceuticals. Nutr Cancer 64:173-97 (2012). Read more (PubMed: 22149093) »
  • Thimmulappa RK  et al. Dibenzoylmethane activates Nrf2-dependent detoxification pathway and inhibits benzo(a)pyrene induced DNA adducts in lungs. Med Chem 4:473-81 (2008). Read more (PubMed: 18782044) »
  • Lin CC  et al. Mechanistic studies on the inhibitory action of dietary dibenzoylmethane, a beta-diketone analogue of curcumin, on 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis. Proc Natl Sci Counc Repub China B 25:158-65 (2001). Read more (PubMed: 11480771) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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