Dibucaine hydrochloride, Local anesthetic (ab145739)

Overview

  • Product name

    Dibucaine hydrochloride, Local anesthetic
  • Description

    Local anesthetic
  • Alternative names

    • 2-Butoxy-N-(2-diethylaminoethyl)-4-quinolinecarboxamide hydrochloride
    • 2-Butoxy-N-(2-diethylaminoethyl)cinchoninamide Hydrochloride
    • 2-Butoxy-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide Hydrochloride
    • 2-butoxy-N-[2-(diethylamino)ethyl]quinoline-4-carboxamide;hydrochloride
    • Benzolin
    • Cincaine
    • Cincaine chloride
    • Cinchocaine hydrochloride
    • Dibucaine (hydrochloride)
    • Dibucaine HCl
    • Nupercaine Hydrochloride
    • Percain
    • Percaine
    • Percamin S
    • Sovcain
    • Sovcaine
    see all
  • Biological description

    Potent and toxic long-acting local anesthetic. Blocks both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade.

  • CAS Number

    61-12-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-Butoxy-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide hydrochloride
  • Molecular weight

    379.92
  • Molecular formula

    C20H29N3O2.HCl
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM, in water to 100 mM and in ethanol to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Seelig A Local anesthetics and pressure: a comparison of dibucaine binding to lipid monolayers and bilayers. Biochim Biophys Acta 899:196-204 (1987). Read more (PubMed: 3580365) »
  • Strichartz G Molecular mechanisms of nerve block by local anesthetics. Anesthesiology 45:421-41 (1976). Read more (PubMed: 9844) »

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