Overview

  • Product name

    DIF-1, cell proliferation inhibitor
  • Description

    Morphogen. Inhibits cancer cell line proliferation and induces cell differentiation.
  • Alternative names

    • Differentiation-inducing factor-1
  • Biological description

    Morphogen that induces differentiation of Dictyostelium discoideum. Inhibits proliferation of cancer cell lines by suppressing Wnt/ β-catenin signaling pathway. Also induces tumor cell differentiation.
  • Purity

    > 98%
  • CAS Number

    111050-72-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1-(3,5-Dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one
  • Molecular weight

    307.20
  • Molecular formula

    C13H16Cl2O4
  • PubChem identifier

    123886
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCCCCC(=O)C1=C(C(=C(C(=C1O)Cl)OC)Cl)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Jingushi K  et al. Differentiation-Inducing Factor-1 Suppresses the Expression of c-Myc in the Human Cancer Cell Lines. J Pharmacol Sci 121:103-9 (2013). Read more (PubMed: 23357875) »
  • Kanai M  et al. Differentiation-inducing factor-1 (DIF-1) inhibits STAT3 activity involved in gastric cancer cell proliferation via MEK-ERK-dependent pathway. Oncogene 22:548-54 (2003). Read more (PubMed: 12555068) »
  • Miwa Y  et al. Differentiation-inducing factor-1, a morphogen of dictyostelium, induces G(1) arrest and differentiation of vascular smooth muscle cells. Circ Res 86:68-75 (0). Read more (PubMed: 10625307) »

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