Overview

  • Product name

    Diflunisal, difluorinated NSAID
  • Description

    Long-acting, difluorinated NSAID
  • Biological description

    Long-acting, difluorinated NSAID. Inhibits production of prostaglandins. Induces L1 promoter activity. Shows analgesic and antipyretic effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    22494-42-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5-(2,4-Difluorophenyl)-2-hydroxybenzoic acid
  • Molecular weight

    250.20
  • Molecular formula

    C13H8F2O3
  • PubChem identifier

    3059
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 100 mM and in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC(=C(C=C1C2=C(C=C(C=C2)F)F)C(=O)O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Di Pietro ME  et al. GET-SERF, a new gradient encoded SERF experiment for the trivial edition of 1H-19F couplings. J Magn Reson 234:101-5 (2013). Read more (PubMed: 23860340) »
  • Terasaki N  et al. In vitro screening for compounds that enhance human l1 mobilization. PLoS One 8:e74629 (2013). Read more (PubMed: 24040300) »
  • Shtrasburg S  et al. Attempts at suppression of amyloidogenesis in a mouse model by a variety of anti-inflammatory agents. Autoimmun Rev 12:18-21 (2012). Read more (PubMed: 22878271) »

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