Dihydrokainic acid, EAAT2 (GLT-1) inhibitor (ab120066)
Key features and details
- EAAT2 (GLT-1) inhibitor
- CAS Number: 52497-36-6
- Soluble in water to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Dihydrokainic acid, EAAT2 (GLT-1) inhibitor -
Description
EAAT2 (GLT-1) inhibitor -
Alternative names
- DHK
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Biological description
Selective, non-transportable inhibitor of glutamate transporter EAAT2 (GLT-1) (Ki = 23 μM). 130-fold selective over EAAT1 and EAAT3 (Ki > 3 mM).
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CAS Number
52497-36-6 -
Chemical structure
Properties
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Chemical name
(2S,3S,4R)-3-(Carboxymethyl)-4-isopropylpyrrolidine-2-carboxylic acid -
Molecular weight
215.25 -
Molecular formula
C10H17NO4 -
PubChem identifier
107883 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)[C@H]1CN[C@@H]([C@H]1CC(=O)O)C(=O)O -
Source
Synthetic
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Research areas
Images
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Chemical Structure - Dihydrokainic acid, EAAT2 (GLT-1) inhibitor (ab120066)2D chemical structure image of ab120066, Dihydrokainic acid, EAAT2 (GLT-1) inhibitor
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (10)
ab120066 has been referenced in 10 publications.
- Zimmer ER et al. [18F]FDG PET signal is driven by astroglial glutamate transport. Nat Neurosci 20:393-395 (2017). PubMed: 28135241
- Armbruster M et al. Glutamate Clearance Is Locally Modulated by Presynaptic Neuronal Activity in the Cerebral Cortex. J Neurosci 36:10404-10415 (2016). PubMed: 27707974
- Yang Y & Xu-Friedman MA Different pools of glutamate receptors mediate sensitivity to ambient glutamate in the cochlear nucleus. J Neurophysiol 113:3634-45 (2015). PubMed: 25855696
- Morioka N et al. Primary cultures of rat cortical microglia treated with nicotine increases in the expression of excitatory amino acid transporter 1 (GLAST) via the activation of the a7 nicotinic acetylcholine receptor. Neuroscience 258:374-84 (2014). PubMed: 24300109
- Naskar K & Stern JE A functional coupling between extrasynaptic NMDA receptors and A-type K+ channels under astrocyte control regulates hypothalamic neurosecretory neuronal activity. J Physiol 592:2813-27 (2014). PubMed: 24835172
- Potapenko ES et al. Astrocytes modulate a postsynaptic NMDA-GABAA-receptor crosstalk in hypothalamic neurosecretory neurons. J Neurosci 33:631-40 (2013). PubMed: 23303942
- Huda R et al. pH modulation of glial glutamate transporters regulates synaptic transmission in the nucleus of the solitary tract. J Neurophysiol 110:368-77 (2013). PubMed: 23615553
- Potapenko ES et al. Altered astrocyte glutamate transporter regulation of hypothalamic neurosecretory neurons in heart failure rats. Am J Physiol Regul Integr Comp Physiol 303:R291-300 (2012). PubMed: 22696576
- Budisantoso T et al. Mechanisms underlying signal filtering at a multisynapse contact. J Neurosci 32:2357-76 (2012). PubMed: 22396411
- Uwechue NM et al. Activation of glutamate transport evokes rapid glutamine release from perisynaptic astrocytes. J Physiol 590:2317-31 (2012). PubMed: 22411007