Dihydrokainic acid, EAAT2 (GLT-1) inhibitor (ab120066)
- Datasheet
- References (9)
Overview
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Product name
Dihydrokainic acid, EAAT2 (GLT-1) inhibitor -
Description
EAAT2 (GLT-1) inhibitor -
Alternative names
- DHK
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Biological description
Selective, non-transportable inhibitor of glutamate transporter EAAT2 (GLT-1) (Ki = 23 μM). 130-fold selective over EAAT1 and EAAT3 (Ki > 3 mM). -
CAS Number
52497-36-6 -
Chemical structure
Properties
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Chemical name
(2S,3S,4R)-3-(Carboxymethyl)-4-isopropylpyrrolidine-2-carboxylic acid -
Molecular weight
215.25 -
Molecular formula
C10H17NO4 -
PubChem identifier
107883 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)[C@H]1CN[C@@H]([C@H]1CC(=O)O)C(=O)O -
Source
Synthetic
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Research areas
References
This product has been referenced in:
- Fallgren AB & Paulsen RE A microdialysis study in rat brain of dihydrokainate, a glutamate uptake inhibitor. Neurochem Res 21:19-25 (1996). Read more (PubMed: 8833219) »
- Arriza JL et al. Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex. J Neurosci 14:5559-69 (1994). Read more (PubMed: 7521911) »
- Muñoz MD et al. Effects of dihydrokainic acid on extracellular amino acids and neuronal excitability in the in vivo rat hippocampus. Neuropharmacology 26:1-8 (1987). Read more (PubMed: 2882438) »
