Overview

  • Product name

    Dimesna, uroprotective agent
  • Description

    Kidney selective prodrug to Mesna
  • Biological description

    Kidney selective (KM values are 636, 390 and 590 μM for OAT1, OAT3, and OAT4 resepectively) prodrug to Mesna (ab142616). Shows uroprotective effects against nephrotoxic agents in vivo. Orally active.
  • CAS Number

    16208-51-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    Disodium 2-(2-sulfonatoethyldisulfanyl)ethanesulfonate
  • Molecular weight

    326.34
  • Molecular formula

    C4H8Na2O6S4
  • PubChem identifier

    65625
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    S(CCSSCCS([O-])(=O)=O)([O-])(=O)=O.[Na+].[Na+]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Cutler MJ  et al. In vitro and in vivo assessment of renal drug transporters in the disposition of mesna and dimesna. J Clin Pharmacol 52:530-42 (2012). Read more (PubMed: 21505084) »
  • Montero AJ & Jassem J Cellular redox pathways as a therapeutic target in the treatment of cancer. Drugs 71:1385-96 (2011). Read more (PubMed: 21812504) »
  • Hausheer FH  et al. Mechanistic study of BNP7787-mediated cisplatin nephroprotection: modulation of human aminopeptidase N. Cancer Chemother Pharmacol 67:381-91 (2011). Read more (PubMed: 20440617) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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