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    dimethoxycurcumin-curcumin-analog-ab144440.pdf

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Dimethoxycurcumin, curcumin analog (ab144440)

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Key features and details

  • Metabolically more stable curcumin analog. Antiproliferative agent.
  • CAS Number: 160096-59-3
  • Purity: > 90%
  • Soluble in DMSO to 10 mM
  • Form / State: Solid
  • Source: Synthetic

Overview

  • Product name

    Dimethoxycurcumin, curcumin analog
  • Description

    Metabolically more stable curcumin analog. Antiproliferative agent.
  • Biological description

    Metabolically more stable curcumin (ab120618, ab141921) analog. Antiproliferative agent. Induces non-cytotoxic G2/M phase cell cycle arrest and apoptosis. Induces the expression of promoter methylated genes. Inhibits NO production, iNOS expression and NF-κB activation. Shows antiproliferative effects (IC50 = 0.5-1 μM).
  • Purity

    > 90%
  • CAS Number

    160096-59-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (1E,6E)-1,7-Bis(3,4-dimethoxyphenyl)hepta-1,6-diene-3,5-dione
  • Molecular weight

    396.44
  • Molecular formula

    C23H24O6
  • PubChem identifier

    9952605
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    COC1=C(C=C(C=C1)/C=C/C(=O)CC(=O)/C=C/C2=CC(=C(C=C2)OC)OC)OC
  • Source

    Synthetic

  • Research areas

    • Biochemicals
    • Product Range
    • New
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    • Chemical Type
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    • Pharmacology
    • Signaling
    • Apoptosis & cell cycle
    • Other
    • Biochemicals
    • Pharmacology
    • Signaling
    • Signal transduction
    • Nitric oxide & oxidative stress
    • NOS
    • Inhibitors

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

    • Datasheet
    • SDS
  • References (0)

    Publishing research using ab144440? Please let us know so that we can cite the reference in this datasheet.

    ab144440 has not yet been referenced specifically in any publications.

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