Dimethyl-bisphenol A, HIF-1alpha inhibitor (ab141642)

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Overview

  • Product name

    Dimethyl-bisphenol A, HIF-1alpha inhibitor

  • Description

    HIF-1α inhibitor

  • Biological description

    HIF-1α inhibitor that promotes degradation of HIF-1α protein by dissociating Hsp90 from HIF-1α. Inhibits steroidogenesis and down regulates rate-limiting enzymes (StAR) in the estradiol biosynthesis pathway.

  • Purity

    > 99%

  • CAS Number

    1568-83-8

  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1,1'-(1-Methylethylidene)bis[4-methoxybenzene

  • Molecular weight

    256.34

  • Molecular formula

    C17H20O2

  • PubChem identifier

    617780

  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

  • Solubility overview

    Soluble in ethanol to 75 mM and in DMSO to 100 mM

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(C)(C1=CC=C(C=C1)OC)C2=CC=C(C=C2)OC

  • Source

    Synthetic

  • Research areas

Associated products

References

This product has been referenced in:

  • Peretz J  et al. Bisphenol A impairs follicle growth, inhibits steroidogenesis, and downregulates rate-limiting enzymes in the estradiol biosynthesis pathway. Toxicol Sci 119:209-17 (2011). Read more (PubMed: 20956811) »
  • Kubo T  et al. Bisphenol A, an environmental endocrine-disrupting chemical, inhibits hypoxic response via degradation of hypoxia-inducible factor 1alpha (HIF-1alpha): structural requirement of bisphenol A for degradation of HIF-1alpha. Biochem Biophys Res Commun 318:1006-11 (2004). Read more (PubMed: 15147973) »

Publishing research using ab141642? Please let us know so that we can cite the reference in this datasheet.

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