Dimethyloxaloylglycine, Prolyl hydroxylase (PHD) inhibitor (ab141586)

Overview

  • Product name

    Dimethyloxaloylglycine, Prolyl hydroxylase (PHD) inhibitor
  • Description

    Prolyl hydroxylase (PHD) inhibitor
  • Biological description

    Cell-permeable prolyl hydroxylase (PHD) inhibitor. Upregulates HIF activity. Active in vivo.
  • Purity

    > 99%
  • CAS Number

    89464-63-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1-(Benzotriazol-1-ylmethyl)benzotriazole
  • Molecular weight

    175.10
  • Molecular formula

    C6H9NO5
  • PubChem identifier

    279626
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC=C2C(=C1)N=NN2CN3C4=CC=CC=C4N=N3
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Ogle ME  et al. Inhibition of prolyl hydroxylases by dimethyloxaloylglycine after stroke reduces ischemic brain injury and requires hypoxia inducible factor-1a. Neurobiol Dis 45:733-42 (2012). Read more (PubMed: 22061780) »
  • Gelse K  et al. Role of hypoxia-inducible factor 1 alpha in the integrity of articular cartilage in murine knee joints. Arthritis Res Ther 10:R111 (2008). Read more (PubMed: 18789153) »
  • Loboda A  et al. HIF-1 attenuates Ref-1 expression in endothelial cells: reversal by siRNA and inhibition of geranylgeranylation. Vascul Pharmacol 51:133-9 (0). Read more (PubMed: 19524065) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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