Diminazene aceturate, Antitrypanosomal agent. ACE activator. (ab143391)

Overview

  • Product name

    Diminazene aceturate, Antitrypanosomal agent. ACE activator.
  • Description

    Antitrypanosomal agent. ACE activator.
  • Biological description

    Antitrypanosomal agent. ACE activator. Inhibits MAPKs and STAT phosphorylation. Suppresses pro-inflammatory cytokine production and shows anti-ischemic effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    908-54-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-[2-(4-Carbamimidoylphenyl)iminohydrazinyl]benzenecarboximidamide aceturate
  • Molecular weight

    515.52
  • Molecular formula

    C14H15N7.2C4H7NO3
  • PubChem identifier

    5284544
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 75 mM and in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(=O)NCC(=O)O.CC(=O)NCC(=O)O.C1=CC(=CC=C1C(=N)N)NN=NC2=CC=C(C=C2)C(=N)N
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Rigatto K  et al. Diminazene aceturate improves autonomic modulation in pulmonary hypertension. Eur J Pharmacol 713:89-93 (2013). Read more (PubMed: 23665493) »
  • Qi Y  et al. Diminazene aceturate enhances angiotensin-converting enzyme 2 activity and attenuates ischemia-induced cardiac pathophysiology. Hypertension 62:746-52 (2013). Read more (PubMed: 23959549) »
  • Kuriakose S  et al. Diminazene aceturate (Berenil) modulates LPS induced pro-inflammatory cytokine production by inhibiting phosphorylation of MAPKs and STAT proteins. Innate Immun : (2013). Read more (PubMed: 24179040) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab143391.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up