Dinaciclib, cyclin-dependent kinase (CDK) inhibitor (ab219469)

Overview

  • Product name

    Dinaciclib, cyclin-dependent kinase (CDK) inhibitor
  • Description

    Novel, potent, selective cyclin-dependent kinase (CDK) inhibitor
  • Alternative names

    • MK-7965
    • SCH 727965
    • SCH727965
  • Biological description

    Novel, potent, selective cyclin-dependent kinase (CDK) inhibitor displaying selectivity for CDK1, CDK2, CDK5 and CDK9 (IC50 values are 3, 1, 1 and 4 nM respectively). Potent DNA replication inhibitor that blocks thymidine incorporation in A2780 ovarian cancer cells (IC50 = 4 nM).

  • Purity

    > 98%
  • CAS Number

    779353-01-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-[(2S)-1-[3-ethyl-7-[(1-oxidopyridin-1-ium-3-yl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]piperidin-2-yl]ethanol
  • Molecular weight

    396.49
  • Molecular formula

    C21H28N6O2
  • PubChem identifier

    46926350
  • Storage instructions

    Shipped at Room Temperature. Store at -20°C. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCC1=C2N=C(C=C(N2N=C1)NCC3=C[N+](=CC=C3)[O-])N4CCCC[C@H]4CCO
  • Source

    Synthetic

References

This product has been referenced in:

  • Chen Z  et al. Multiple CDK inhibitor dinaciclib suppresses neuroblastoma growth via inhibiting CDK2 and CDK9 activity. Sci Rep 6:29090 (2016). Read more (PubMed: 27378523) »
  • Flynn J  et al. Dinaciclib is a novel cyclin-dependent kinase inhibitor with significant clinical activity in relapsed and refractory chronic lymphocytic leukemia. Leukemia 29:1524-9 (2015). Read more (PubMed: 25708835) »
  • Parry D  et al. Dinaciclib (SCH 727965), a novel and potent cyclin-dependent kinase inhibitor. Mol Cancer Ther 9:2344-53 (2010). Read more (PubMed: 20663931) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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