Product nameDiosgenin, Apopotic and antioxidant agent
DescriptionSteroidal saponin. Apopotic and antioxidant agent.
Biological descriptionSteroidal saponin. Apopotic and antioxidant agent. Promotes angiogenesis in a HIF-1α dependent mechanism. Shows anticancer and immunosuppressive effects in vivo. Inhibits STAT3, PI3K, Akt, ERK and JNK phosphorylation and proinflammatory cytokine production. Orally active.
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Signal transduction
- Nitric oxide & oxidative stress
This product has been referenced in:
- Jagadeesan J et al. Diosgenin, a steroidal saponin, exhibits anticancer activity by attenuating lipid peroxidation via enhancing antioxidant defense system during NMU-induced breast carcinoma. J Environ Pathol Toxicol Oncol 31:121-9 (2012). Read more (PubMed: 23216637) »
- Liu MJ et al. Diosgenin induces cell cycle arrest and apoptosis in human leukemia K562 cells with the disruption of Ca2+ homeostasis. Cancer Chemother Pharmacol 55:79-90 (2005). Read more (PubMed: 15372201) »
- Yen ML et al. Diosgenin induces hypoxia-inducible factor-1 activation and angiogenesis through estrogen receptor-related phosphatidylinositol 3-kinase/Akt and p38 mitogen-activated protein kinase pathways in osteoblasts. Mol Pharmacol 68:1061-73 (2005). Read more (PubMed: 15998873) »