Overview

  • Product name

    Diosgenin, Apopotic and antioxidant agent
  • Description

    Steroidal saponin. Apopotic and antioxidant agent.
  • Biological description

    Steroidal saponin. Apopotic and antioxidant agent. Promotes angiogenesis in a HIF-1α dependent mechanism. Shows anticancer and immunosuppressive effects in vivo. Inhibits STAT3, PI3K, Akt, ERK and JNK phosphorylation and proinflammatory cytokine production. Orally active.
  • Purity

    > 98%
  • CAS Number

    512-04-9
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Jagadeesan J  et al. Diosgenin, a steroidal saponin, exhibits anticancer activity by attenuating lipid peroxidation via enhancing antioxidant defense system during NMU-induced breast carcinoma. J Environ Pathol Toxicol Oncol 31:121-9 (2012). Read more (PubMed: 23216637) »
  • Liu MJ  et al. Diosgenin induces cell cycle arrest and apoptosis in human leukemia K562 cells with the disruption of Ca2+ homeostasis. Cancer Chemother Pharmacol 55:79-90 (2005). Read more (PubMed: 15372201) »
  • Yen ML  et al. Diosgenin induces hypoxia-inducible factor-1 activation and angiogenesis through estrogen receptor-related phosphatidylinositol 3-kinase/Akt and p38 mitogen-activated protein kinase pathways in osteoblasts. Mol Pharmacol 68:1061-73 (2005). Read more (PubMed: 15998873) »

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