Overview

  • Product name

    Anti-DIPP antibody
  • Description

    Rabbit polyclonal to DIPP
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human DIPP aa 1-156.
    Database link: O95989

  • Positive control

    • IMR32 whole cell lysate; Human lung adenocarcinoma tissue.
  • General notes

    Previously labelled as NUDT3. 

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.00
    Preservative: 0.025% Proclin
    Constituents: PBS, 1% BSA, 20% Glycerol
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab126962 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 19 kDa.
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphophate) is not a substrate. Acts as a negative regulator of the ERK1/2 pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.
  • Tissue specificity

    Widely expressed. Expressed at higher level in brain, heart, pancreas and liver. Also expressed in placenta, lung and kidney.
  • Sequence similarities

    Belongs to the Nudix hydrolase family. DIPP subfamily.
    Contains 1 nudix hydrolase domain.
  • Cellular localization

    Cytoplasm.
  • Information by UniProt
  • Database links

  • Alternative names

    • 5''''-P1 antibody
    • Diadenosine 5' 5''' P1 P6 hexaphosphate hydrolase 1 antibody
    • Diadenosine 5'' antibody
    • Diphosphoinositol polyphosphate phosphohydrolase 1 antibody
    • Diphosphoinositol polyphosphate phosphohydrolase antibody
    • DIPP 1 antibody
    • DIPP antibody
    • DIPP-1 antibody
    • DIPP1 antibody
    • Nucleoside diphosphate linked moiety X motif 3 antibody
    • Nucleoside diphosphate-linked moiety X motif 3 antibody
    • Nudix (nucleoside diphosphate linked moiety X) type motif 3 antibody
    • Nudix motif 3 antibody
    • Nudix type motif 3 antibody
    • NUDT 3 antibody
    • Nudt3 antibody
    • NUDT3_HUMAN antibody
    • P6-hexaphosphate hydrolase 1 antibody
    see all

Images

  • Anti-DIPP antibody (ab126962) at 1/1000 dilution + IMR32 whole cell lysate at 30 µg

    Predicted band size: 19 kDa



    12% SDS PAGE
  • ab126962, at a dilution of 1/500, staining DIPP in paraffin-embedded Human lung adenocarcinoma tissue by Immunohistochemistry.

References

ab126962 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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