• Product name

  • Description

    Rabbit polyclonal to DIS
  • Host species

  • Tested applications

    Suitable for: WB, IPmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Dog, Chimpanzee, Rhesus monkey, Elephant
  • Immunogen

    Region between residue 1100 and the C terminus (residue 1150) of human DIS

  • Positive control

    • Nuclear extract from HeLa cells



Our Abpromise guarantee covers the use of ab70245 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notes
    IP: Use at 1-10µg/mg of lysate.
    WB: 1/1000 - 1/10000. Detects a band of approximately 132 kDa (predicted molecular weight: 132 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function

      Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation.
    • Tissue specificity

      Expressed in various epithelial cancer cell lines, including breast, colon, prostate, pancreatic and leukemia. Expression is regulated by growth factors.
    • Sequence similarities

      Contains 1 SAP domain.
    • Post-translational

      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • Cellular localization

      Cytoplasm > perinuclear region.
    • Information by UniProt
    • Database links

    • Alternative names

      • CARP-1 antibody
      • Carp1 antibody
      • Ccar1 antibody
      • CCAR1_HUMAN antibody
      • Cell cycle and apoptosis regulatory protein 1 antibody
      • cell division cycle and apoptosis regulator 1 antibody
      • Cell division cycle and apoptosis regulator protein 1 antibody
      • Death inducer with SAP domain antibody
      • FLJ10590 antibody
      • FLJ10839 antibody
      • FLJ13376 antibody
      • FLJ20734 antibody
      • MGC7730 antibody
      • RP11-437A18.1 antibody
      see all


    • Lanes 1-2 : Anti-DIS antibody (ab70245) at 1 µg/ml
      Lanes 3-4 : Anti-DIS antibody (ab70245) at 0.2 µg/ml

      Lanes 1 & 3 : Nuclear extract from HeLa cells at 15 µg
      Lanes 2 & 4 : Nuclear extract from HeLa cells at 45 µg

      Developed using the ECL technique.

      Predicted band size: 132 kDa
      Observed band size: 132 kDa

      Exposure time: 1 minute
    • Detection of Human CCAR1 by Immunoprecipitation using Nuclear extract (100 µg) from HeLa cells and Affinity purified rabbit anti-CCAR1 ab70245 at 1 µg/100 µg Nuclear extract. Chemiluminescence with exposure times of approximately 3 seconds.


    ab70245 has not yet been referenced specifically in any publications.

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