Overview

  • Product name
    Anti-Dishevelled / Dvl1 antibody
    See all Dishevelled / Dvl1 primary antibodies
  • Description
    Goat polyclonal to Dishevelled / Dvl1
  • Host species
    Goat
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Rat, Human, Chimpanzee
  • Immunogen

    Synthetic peptide corresponding to Mouse Dishevelled/ Dvl1 aa 402-414 (internal sequence) (Cysteine residue).
    Sequence:

    PQLEEAPLTVKSD


    Database link: NP_034221.3

  • Positive control
    • NIH3T3 lysate

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 99% Tris buffered saline, 0.5% BSA
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab174679 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 75 kDa.

Target

  • Function
    Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).
  • Involvement in disease
    Robinow syndrome, autosomal dominant 2
  • Sequence similarities
    Belongs to the DSH family.
    Contains 1 DEP domain.
    Contains 1 DIX domain.
    Contains 1 PDZ (DHR) domain.
  • Domain
    The DIX domain promotes homooligomerization.
    The DEP domain mediates interaction with the cell membrane.
  • Post-translational
    modifications
    Ubiquitinated; undergoes both 'Lys-48'-linked ubiquitination, leading to its subsequent degradation by the ubiquitin-proteasome pathway, and 'Lys-63'-linked ubiquitination. The interaction with INVS is required for ubiquitination. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains.
  • Cellular localization
    Cell membrane. Cytoplasm, cytosol. Cytoplasmic vesicle. Localizes at the cell membrane upon interaction with frizzled family members.
  • Information by UniProt
  • Database links
  • Form
    There are 2 isoforms produced by alternative splicing.
  • Alternative names
    • Dishevelled 1 antibody
    • dishevelled 1 like antibody
    • Dishevelled antibody
    • Dishevelled dsh homolog 1 antibody
    • Dishevelled-1 antibody
    • Dishevelled1 antibody
    • DSH homolog 1 antibody
    • Dvl 1 antibody
    • Dvl antibody
    • Dvl1 antibody
    • DVL1_HUMAN antibody
    • DVL1L1 antibody
    • MGC54245 antibody
    • Segment polarity protein dishevelled homolog DVL 1 antibody
    • segment polarity protein dishevelled homolog DVL 1 like antibody
    • Segment polarity protein dishevelled homolog DVL-1 antibody
    • Segment polarity protein dishevelled homolog DVL1 antibody
    see all

Images

  • Anti-Dishevelled / Dvl1 antibody (ab174679) at 1 µg/ml + NIH3T3 lysate at 35 µg

    Predicted band size: 75 kDa
    Additional bands at: 45 kDa (possible cross reactivity)

References

This product has been referenced in:
  • Minashima T & Kirsch T Annexin A6 regulates catabolic events in articular chondrocytes via the modulation of NF-?B and Wnt/ß-catenin signaling. PLoS One 13:e0197690 (2018). Read more (PubMed: 29771996) »
See 1 Publication for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab174679.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up