Overview

  • Product name

    Disuccinimidyl suberate, cross-linking reagent
  • Description

    Homobifunctional primary amine reactive cross-linker
  • Alternative names

    • DSS
  • Biological description

    Homobifunctional primary amine reactive cross-linker. Contains an 8 atom linker (11.4 Å) and can cross-link distances up to ~25 Å due to protein flexibility. Produces no toxic side products.
  • Purity

    > 99%
  • CAS Number

    68528-80-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    Octanedioic acid 1,8-bis(2,5-dioxo-1-pyrrolidinyl) ester
  • Molecular weight

    368.34
  • Molecular formula

    C16H20N2O8
  • PubChem identifier

    100658
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    O=C2CCC(=O)N2OC(=O)CCCCCCC(=O)ON1C(=O)CCC1=O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Scurtu F  et al. Hemoglobin-albumin cross-linking with disuccinimidyl suberate (DSS) and/or glutaraldehyde for blood substitutes. Artif Cells Nanomed Biotechnol : (2013). Read more (PubMed: 23342991) »
  • Chavez JD  et al. Quantification of protein-protein interactions with chemical cross-linking and mass spectrometry. J Proteome Res 10:1528-37 (2011). Read more (PubMed: 21222489) »
  • Paglin S & Jamieson JD Covalent crosslinking of angiotensin II to its binding sites in rat adrenal membranes. Proc Natl Acad Sci U S A 79:3739-43 (1982). Read more (PubMed: 6285362) »

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