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    dkk1-antibody-c-terminal-ab188597.pdf

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Immunology Immune Interventions Transplantation
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Anti-DKK1 antibody - C-terminal (ab188597)

  • Datasheet
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DKK1 antibody - C-terminal (ab188597)

    Key features and details

    • Goat polyclonal to DKK1 - C-terminal
    • Suitable for: IHC-P
    • Reacts with: Human
    • Isotype: IgG

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    Protein
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    Recombinant human DKK1 protein (ab155623)

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    Overview

    • Product name

      Anti-DKK1 antibody - C-terminal
      See all DKK1 primary antibodies
    • Description

      Goat polyclonal to DKK1 - C-terminal
    • Host species

      Goat
    • Tested applications

      Suitable for: IHC-Pmore details
    • Species reactivity

      Reacts with: Human
      Predicted to work with: Mouse, Rat, Rabbit, Goat, Horse, Hamster, Cow, Dog, Pig, Monkey, Gorilla, Common marmoset, Bat, Platypus
    • Immunogen

      Synthetic peptide corresponding to Human DKK1 aa 250 to the C-terminus (Cysteine residue).
      Database link: O94907

      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
    • Positive control

      • Human placenta
    • General notes

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
    • Storage buffer

      pH: 7.30
      Preservative: 0.02% Sodium azide
      Constituents: 99% Tris buffered saline, 0.5% BSA
    • Concentration information loading...
    • Purity

      Immunogen affinity purified
    • Clonality

      Polyclonal
    • Isotype

      IgG
    • Research areas

      • Immunology
      • Immune Interventions
      • Transplantation
      • Cardiovascular
      • Blood
      • Other
      • Stem Cells
      • Signaling Pathways
      • Wnt
      • Secreted
      • Developmental Biology
      • Embryogenesis
      • Axis formation and symmetry

    Associated products

    • Compatible Secondaries

      • Donkey Anti-Goat IgG H&L (Alexa Fluor® 488) (ab150129)
      • Donkey Anti-Goat IgG H&L (HRP) (ab205723)
    • Isotype control

      • Goat IgG, polyclonal - Isotype Control (ab37373)
    • Recombinant Protein

      • Recombinant human DKK1 protein (ab155623)
    • Related Products

      • Recombinant human DKK1 protein (ab155623)
      • Recombinant Human DKK1 protein (denatured) (ab156969)

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab188597 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    IHC-P
    Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
    Notes
    IHC-P
    Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

    Target

    • Function

      Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
    • Tissue specificity

      Placenta.
    • Sequence similarities

      Belongs to the dickkopf family.
    • Domain

      The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.
    • Cellular localization

      Secreted.
    • Target information above from: UniProt accession O94907 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 504445 Cow
      • Entrez Gene: 609600 Dog
      • Entrez Gene: 102182190 Goat
      • Entrez Gene: 101147272 Gorilla
      • Entrez Gene: 101827192 Hamster
      • Entrez Gene: 100071881 Horse
      • Entrez Gene: 22943 Human
      • Entrez Gene: 13380 Mouse
      • Entrez Gene: 100157640 Pig
      • Entrez Gene: 293897 Rat
      • Omim: 605189 Human
      • SwissProt: O94907 Human
      • SwissProt: O54908 Mouse
      • Unigene: 40499 Human
      • Unigene: 214717 Mouse
      see all
    • Alternative names

      • Dickkopf 1 antibody
      • Dickkopf 1 homolog antibody
      • Dickkopf 1 like antibody
      • Dickkopf homolog 1 antibody
      • Dickkopf like protein 1 antibody
      • Dickkopf related protein 1 antibody
      • Dickkopf WNT signaling pathway inhibitor 1 antibody
      • Dickkopf-1 antibody
      • Dickkopf-related protein 1 antibody
      • DKK 1 antibody
      • Dkk-1 antibody
      • Dkk1 antibody
      • DKK1_HUMAN antibody
      • hDkk 1 antibody
      • hDkk-1 antibody
      • SK antibody
      see all

    Images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DKK1 antibody - C-terminal (ab188597)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DKK1 antibody - C-terminal (ab188597)

      Immunohistochemical analysis of formalin fixed paraffin embedded human placenta labeling DKK1 with ab188597 at 10 µg/ml

    Protocols

    • Immunohistochemistry protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet download

      Download

    References (2)

    Publishing research using ab188597? Please let us know so that we can cite the reference in this datasheet.

    ab188597 has been referenced in 2 publications.

    • Workman A  et al. The Wnt Signaling Pathway Is Differentially Expressed during the Bovine Herpesvirus 1 Latency-Reactivation Cycle: Evidence That Two Protein Kinases Associated with Neuronal Survival, Akt3 and BMPR2, Are Expressed at Higher Levels during Latency. J Virol 92:N/A (2018). PubMed: 29321317
    • Himburg HA  et al. Dickkopf-1 promotes hematopoietic regeneration via direct and niche-mediated mechanisms. Nat Med 23:91-99 (2017). PubMed: 27918563

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