Key features and details
- NMDA glutamate site antagonist
- CAS Number: 76326-31-3
- Purity: > 99%
- Soluble in water to 25 mM and in 1 eq. NaOH to 100 mM
- Form / State: Solid
- Source: Synthetic
Product nameDL-AP5, NMDA glutamate site antagonist
DescriptionNMDA glutamate site antagonist
Competitive NMDA receptor glutamate site antagonist. Also available as the sodium salt (ab120271).
Chemical nameDL-2-Amino-5-phosphonopentanoic acid
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 25 mM and in 1 eq. NaOH to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120004 has been referenced in 77 publications.
- Erli F et al. Estradiol reverses excitatory synapse loss in a cellular model of neuropsychiatric disorders. Transl Psychiatry 10:16 (2020). PubMed: 32066698
- Sahu G et al. Junctophilin Proteins Tether a Cav1-RyR2-KCa3.1 Tripartite Complex to Regulate Neuronal Excitability. Cell Rep 28:2427-2442.e6 (2019). PubMed: 31461656
- Jones KA et al. Loss of EPAC2 alters dendritic spine morphology and inhibitory synapse density. Mol Cell Neurosci 98:19-31 (2019). PubMed: 31059774
- Loo L et al. Single-cell transcriptomic analysis of mouse neocortical development. Nat Commun 10:134 (2019). PubMed: 30635555
- Sellers KJ et al. Amyloid ß synaptotoxicity is Wnt-PCP dependent and blocked by fasudil. Alzheimers Dement 14:306-317 (2018). PubMed: 29055813