DL-AP5 sodium salt, NMDA glutamate site antagonist (ab120271)
Key features and details
- NMDA glutamate site antagonist. Water soluble form.
- CAS Number: 1303993-72-7
- Purity: > 99%
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
DL-AP5 sodium salt, NMDA glutamate site antagonist -
Description
NMDA glutamate site antagonist. Water soluble form. -
Biological description
Competitive NMDA receptor glutamate site antagonist. Water soluble form.
Also available in simple stock solutions (ab144498) - add 1 ml of water to get an exact, ready-to-use concentration. -
Purity
> 99% -
CAS Number
1303993-72-7 -
Chemical structure
Properties
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Chemical name
DL-2-Amino-5-phosphonopentanoic acid sodium salt -
Molecular weight
219.11 -
Molecular formula
C5H11NNaO5P -
PubChem identifier
52974251 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=P(O)(CCCC(N)C(=O)O)O[Na] -
Source
Synthetic
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Research areas
Images
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Chemical Structure - DL-AP5 sodium salt, NMDA glutamate site antagonist (ab120271)2D chemical structure image of ab120271, DL-AP5 sodium salt, NMDA glutamate site antagonist
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (14)
ab120271 has been referenced in 14 publications.
- Booker SA et al. Presynaptic GABAB receptors functionally uncouple somatostatin interneurons from the active hippocampal network. Elife 9:N/A (2020). PubMed: 32073397
- Cover KK et al. Activation of the Rostral Intralaminar Thalamus Drives Reinforcement through Striatal Dopamine Release. Cell Rep 26:1389-1398.e3 (2019). PubMed: 30726725
- Raja MK et al. Elevated synaptic vesicle release probability in synaptophysin/gyrin family quadruple knockouts. Elife 8:N/A (2019). PubMed: 31090538
- Styr B et al. Mitochondrial Regulation of the Hippocampal Firing Rate Set Point and Seizure Susceptibility. Neuron 102:1009-1024.e8 (2019). PubMed: 31047779
- Ge Y et al. Clptm1 Limits Forward Trafficking of GABAA Receptors to Scale Inhibitory Synaptic Strength. Neuron 97:596-610.e8 (2018). PubMed: 29395912