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    dl-ap5-sodium-salt-nmda-glutamate-site-antagonist-ab120271.pdf

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Neuroscience Neurotransmitter Amino Acids Glutamate
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DL-AP5 sodium salt, NMDA glutamate site antagonist (ab120271)

  • Datasheet
  • SDS
  • COA
Submit a review Q&A (4)References (17)

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Chemical Structure - DL-AP5 sodium salt, NMDA glutamate site antagonist (ab120271)

    Key features and details

    • NMDA glutamate site antagonist. Water soluble form.
    • CAS Number: 1303993-72-7
    • Soluble in water to 100 mM
    • Form / State: Solid
    • Source: Synthetic

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    Overview

    • Product name

      DL-AP5 sodium salt, NMDA glutamate site antagonist
    • Description

      NMDA glutamate site antagonist. Water soluble form.
    • Biological description

      Competitive NMDA receptor glutamate site antagonist. Water soluble form.

      Also available in simple stock solutions (ab144498) - add 1 ml of water to get an exact, ready-to-use concentration.

    • CAS Number

      1303993-72-7
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      DL-2-Amino-5-phosphonopentanoic acid sodium salt
    • Molecular weight

      219.11
    • Molecular formula

      C5H11NNaO5P
    • PubChem identifier

      52974251
    • Storage instructions

      Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
    • Solubility overview

      Soluble in water to 100 mM
    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      O=P(O)(CCCC(N)C(=O)O)O[Na]
    • Source

      Synthetic

    • Research areas

      • Neuroscience
      • Neurotransmitter
      • Amino Acids
      • Glutamate
      • Neuroscience
      • Neurotransmission
      • Receptors / Channels
      • GPCR
      • Glutamate Receptors
      • Neuroscience
      • Neurotransmission
      • Receptors / Channels
      • Ligand-Gated Ion Channels
      • AMPA / Kainate
      • Biochemicals
      • Product Range
      • Just Add Water
      • Biochemicals
      • Chemical Type
      • Amino Acid
      • Biochemicals
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      • Pharmacology
      • Receptors & Transporters
      • Glutamate
      • NMDA
      • Biochemicals
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      • Receptors & Transporters
      • Glutamate
      • NMDA
      • Glutamate Site
      • Antagonists
      • Biochemicals
      • Research Area
      • Addiction
      • Glutamate
      • NMDA
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      • NMDA
      • Glutamate Site
      • Antagonists
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      • Glutamate
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      • Biochemicals
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      • Alzheimer's Disease
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      • Antagonists
      • Biochemicals
      • Research Area
      • Depression
      • Glutamate
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      • Biochemicals
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      • Depression
      • Glutamate
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      • Antagonists
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      • NMDA
      • Biochemicals
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      • Pain & inflammation
      • Glutamate
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      • NMDA
      • Biochemicals
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      • Research Area
      • Stroke
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      • NMDA
      • Biochemicals
      • Research Area
      • Stroke
      • Glutamate
      • NMDA
      • Glutamate Site
      • Antagonists
      • Neuroscience
      • Processes

    Images

    • Chemical Structure - DL-AP5 sodium salt, NMDA glutamate site antagonist (ab120271)
      Chemical Structure - DL-AP5 sodium salt, NMDA glutamate site antagonist (ab120271)
      2D chemical structure image of ab120271, DL-AP5 sodium salt, NMDA glutamate site antagonist

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download
    • COA

    References (17)

    Publishing research using ab120271? Please let us know so that we can cite the reference in this datasheet.

    ab120271 has been referenced in 17 publications.

    • Ivanova D  et al. Control of synaptic vesicle release probability via VAMP4 targeting to endolysosomes. Sci Adv 7:N/A (2021). PubMed: 33931449
    • Luo X  et al. Synaptic Mechanisms Underlying the Network State-Dependent Recruitment of VIP-Expressing Interneurons in the CA1 Hippocampus. Cereb Cortex 30:3667-3685 (2020). PubMed: 32080739
    • Yong XLH  et al. PICK1 Controls Activity-Dependent Synaptic Vesicle Cargo Retrieval. Cell Rep 33:108312 (2020). PubMed: 33113376
    • Booker SA  et al. Presynaptic GABAB receptors functionally uncouple somatostatin interneurons from the active hippocampal network. Elife 9:N/A (2020). PubMed: 32073397
    • Cover KK  et al. Activation of the Rostral Intralaminar Thalamus Drives Reinforcement through Striatal Dopamine Release. Cell Rep 26:1389-1398.e3 (2019). PubMed: 30726725
    View all Publications for this product

    Customer reviews and Q&As

    Show All Reviews Q&A
    Submit a review Submit a question

    1-4 of 4 Abreviews or Q&A

    Question

    Why the molecular weight is different for each vial?

    Read More

    Abcam community

    Verified customer

    Asked on Feb 13 2013

    Answer

    Thank you for contacting us.

    The molecular weight for biochemicals is batch dependant, which is why it is different for each batch. Please check the certificate of analysis on website for more information.

    I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

    Read More

    Abcam Scientific Support

    Answered on Feb 13 2013

    Question

    I would like to have an updated MSDS for the product #ASC-271 DL-AP5 SODIUM SALT (in french if available).
    I was unable to find it on your website.
    Thank you

    Read More

    Abcam community

    Verified customer

    Asked on Jan 27 2012

    Answer

    Thank you for contacting Abcam.

    I have attached the most up to date MSDS we have for ab120271, DL-AP5 SODIUM SALT. The MSDS for this product is also available on our webpage. I am sorry that I do not have it in French at the minute, but I will email one of my colleagues to find out if we can supply one and will let you know if we can.

    If there is anything else I can help you with, please let me know.

    Read More

    Abcam Scientific Support

    Answered on Jan 27 2012

    Question

    What will be the pH of this solution when it is dissolved in water?

    Read More

    Abcam community

    Verified customer

    Asked on Jan 27 2012

    Answer

    Thank you for your recent technical enquiry.

    I can confirm DL-AP5 sodium salt is pH6 when dissolved in water.
    If you have any further questions regarding this compound please do not hesitate to contact us

    Read More

    Abcam Scientific Support

    Answered on Jan 27 2012

    Question

    What is the pH of this biochemical? Have you tested it in a brain iron ferritin experiment? At what pH should this be done?

    Read More

    Abcam community

    Verified customer

    Asked on Jan 20 2012

    Answer

    Thank you for your inquiry. Abcam biochemicals are novel compounds and we have not tested their biological activity in house. As such, we can only offer advice based on published literature. Unfortunately I am unable to find specific examples of DL-AP5 sodium salt usage in a ferritin/iron brain assay. However following pH testing, I can confirm the pH of DL-AP5 sodium salt as pH6. We also recommend consulting literature when identifying how to use our products effectively.


    I hope that this information is useful and if you have any further questions, please do not hesitate to contact me.

    Read More

    Abcam Scientific Support

    Answered on Jan 20 2012

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
    For licensing inquiries, please contact partnerships@abcam.com

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