Product nameD,L-Buthionine-(S,R)-sulfoximine, gamma-glutamyl cysteine synthase inhibitor
DescriptionWater soluble, potent, selective inhibitor of gamma-glutamyl cysteine synthase.
- 2-Amino-4-(S-butylsulfonimidoyl)butanoic Acid
- Buthionine Sulfoximine
Water soluble, potent, selective inhibitor of gamma-glutamyl cysteine synthase. Depletes cellular glutathione.
Chemical name2-Amino-4-(S-butylsulfonimidoyl)butanoic acid
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This product has been referenced in:
- Srivastava SK et al. Potentiation of benzo[a]pyrene-induced pulmonary and forestomach tumorigenesis in mice by D,L-buthionine-S,R-sulfoximine-mediated tissue glutathione depletion. Cancer Lett 153:35-9 (2000). Read more (PubMed: 10779627) »
- Bertsche U & Schorn H Glutathione depletion by DL-buthionine-SR-sulfoximine (BSO) potentiates X-ray-induced chromosome lesions after liquid holding recovery. Radiat Res 105:351-69 (1986). Read more (PubMed: 3754339) »