DL-Carbidopa (Carbidopa), Aromatic amino acid decarboxylase inhibitor (ab144725)

Overview

  • Product name

    DL-Carbidopa (Carbidopa), Aromatic amino acid decarboxylase inhibitor
  • Description

    Noncompetitive aromatic amino acid decarboxylase inhibitor
  • Alternative names

    • Carbidopa
  • Biological description

    Noncompetitive aromatic amino acid decarboxylase inhibitor. Inhibits peripheral L-DOPA (ab120565) metabolism to dopamine and inhibits decarboxylation of L-5-Hydroxytryptophan (ab142520) to serotonin in vivo. Orally active.
  • CAS Number

    302-53-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-(3,4-Dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid
  • Molecular weight

    226.23
  • Molecular formula

    C10H14N2O4
  • PubChem identifier

    2563
  • Storage instructions

    Store at -20°C. Store In the Dark. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
  • Solubility overview

    Soluble in DMSO to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(CC1=CC(=C(C=C1)O)O)(C(=O)O)NN
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Agmo A & Villalpando A Central nervous stimulants facilitate sexual behavior in male rats with medial prefrontal cortex lesions. Brain Res 696:187-93 (1995). Read more (PubMed: 8574668) »
  • Bredberg E  et al. Pharmacokinetics of levodopa and carbidopa in rats following different routes of administration. Pharm Res 11:549-55 (1994). Read more (PubMed: 8058614) »
  • Nissbrandt H  et al. The influence of serotoninergic drugs on dopaminergic neurotransmission in rat substantia nigra, striatum and limbic forebrain in vivo. Naunyn Schmiedebergs Arch Pharmacol 346:12-9 (1992). Read more (PubMed: 1328893) »

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