D,L-threo-beta-Hydroxyaspartic acid, glutamate uptake transporter inhibitor (ab144768)

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Overview

  • Product name

    D,L-threo-beta-Hydroxyaspartic acid, glutamate uptake transporter inhibitor

  • Description

    Selective glutamate uptake transporter inhibitor

  • Biological description

    Selective glutamate uptake transporter inhibitor. Shows neuroprotective effects in vivo. Centrally active.

  • Purity

    > 98%

  • CAS Number

    4294-45-5

  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    threo-2-Amino-3-hydroxysuccinic acid

  • Molecular weight

    149.10

  • Molecular formula

    C4H7NO5

  • PubChem identifier

    443239

  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

  • Solubility overview

    Soluble in 1 eq. NaOH to 100 mM

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    [C@H]([C@@H](C(=O)O)O)(C(=O)O)N

  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Cao BB  et al. Cerebellar fastigial nuclear glutamatergic neurons regulate immune function via hypothalamic and sympathetic pathways. J Neuroimmune Pharmacol 10:162-78 (2015). Read more (PubMed: 25649846) »
  • Martínez D  et al. An acute glutamate exposure induces long-term down regulation of GLAST/EAAT1 uptake activity in cultured Bergmann glia cells. Neurochem Res 39:142-9 (2014). Read more (PubMed: 24248861) »
  • Shimamoto K  et al. DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters. Mol Pharmacol 53:195-201 (1998). Read more (PubMed: 9463476) »

Publishing research using ab144768? Please let us know so that we can cite the reference in this datasheet.

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