D,L-threo-PPMP, Glucosylceramide synthase inhibitor (ab144023)

Overview

  • Product name

    D,L-threo-PPMP, Glucosylceramide synthase inhibitor
  • Description

    Glucosylceramide synthase inhibitor
  • Biological description

    Glucosylceramide synthase inhibitor. Useful in ER anterograde trafficking studies. Anticancer and antimalarial (IC50 = 0.85 µM) agent. Active in vitro.

    See similar compounds
  • Purity

    > 98%
  • CAS Number

    149022-18-4
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Bleicher RJ & Cabot MC Glucosylceramide synthase and apoptosis. Biochim Biophys Acta 1585:172-8 (2002). Read more (PubMed: 12531551) »
  • Nakamura M  et al. Glucosylceramide synthesis inhibitors block pharmacologically induced dispersal of the Golgi and anterograde membrane flow from the endoplasmic reticulum: implication of sphingolipid metabolism in maintenance of the Golgi architecture and anterograde membrane flow. Biosci Biotechnol Biochem 65:1369-78 (2001). Read more (PubMed: 11471737) »
  • Lauer SA  et al. Sphingolipid synthesis as a target for chemotherapy against malaria parasites. Proc Natl Acad Sci U S A 92:9181-5 (1995). Read more (PubMed: 7568097) »

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