Overview

  • Product name
    Anti-DLC1 antibody
    See all DLC1 primary antibodies
  • Description
    Rabbit polyclonal to DLC1
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to a region within C terminal amino acids 1271 -1516 of Human DLC1 (Q96QB1).

  • Positive control
    • A549 and HepG2 cell lysates and Human Breast ca tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab126257 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 171 kDa.
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Functions as a GTPase-activating protein specific for Rho and an activator of PLCD1 in vivo and induces morphological changes and detachment through cytoskeletal reorganization.
  • Tissue specificity
    Highest level of expression in the spleen, with rather lower levels in prostate, testis, ovary, small intestine and colon, but none in the thymus.
  • Sequence similarities
    Contains 1 Rho-GAP domain.
    Contains 1 SAM (sterile alpha motif) domain.
    Contains 1 START domain.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt
  • Database links
    • Alternative names
      • ARHGAP 7 antibody
      • ARHGAP7 antibody
      • Deleted in liver cancer 1 antibody
      • Deleted in liver cancer 1 protein antibody
      • DLC 1 antibody
      • Dlc-1 antibody
      • DLC1 antibody
      • DLC1 Rho GTPase activating protein antibody
      • FLJ21120 antibody
      • HP antibody
      • HP protein antibody
      • KIAA1723 antibody
      • p122 RhoGAP antibody
      • RHG07_HUMAN antibody
      • Rho GTPase activating protein 7 antibody
      • Rho GTPase-activating protein 7 antibody
      • Rho type GTPase activating protein 7 antibody
      • Rho-type GTPase-activating protein 7 antibody
      • StAR related lipid transfer (START) domain containing 12 antibody
      • StAR related lipid transfer protein 12 antibody
      • StAR-related lipid transfer protein 12 antibody
      • STARD 12 antibody
      • StARD12 antibody
      • START domain containing protein 12 antibody
      • START domain-containing protein 12 antibody
      see all

    Images

    • Western blot - Anti-DLC1 antibody (ab126257)
      Western blot - Anti-DLC1 antibody (ab126257)
      Anti-DLC1 antibody (ab126257) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg

      Predicted band size: 171 kDa



      Gel concentration: 5%
    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DLC1 antibody (ab126257)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DLC1 antibody (ab126257)
      ab126257, at 1/500, staining DLC1 in Human Breast ca tissue by immunohistochemistry [Paraffin Embedded Tissues (IHC-P).

    References

    This product has been referenced in:
    • Ye Y  et al. Exosomal miR-141-3p regulates osteoblast activity to promote the osteoblastic metastasis of prostate cancer. Oncotarget 8:94834-94849 (2017). Read more (PubMed: 29212270) »
    • Xiao P  et al. miR-429 promotes the proliferation of non-small cell lung cancer cells via targeting DLC-1. Oncol Lett 12:2163-2168 (2016). WB ; Human . Read more (PubMed: 27602157) »

    See all 2 Publications for this product

    Publishing research using ab126257? Please let us know so that we can cite the reference in this datasheet.

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