Key features and details
- Goat polyclonal to DLL4
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Product nameAnti-DLL4 antibody
See all DLL4 primary antibodies
DescriptionGoat polyclonal to DLL4
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Mouse, Rat, Human
- Human, mouse and rat lung lysates.
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 99% Tris buffered saline, 0.5% BSA
Concentration information loading...
PurityImmunogen affinity purified
Purification notesab183532 was purified from goat serum by ammonium sulfate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Our Abpromise guarantee covers the use of ab183532 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 0.1 - 1 µg/ml. Detects a band of approximately 80-85 kDa (predicted molecular weight: 74 kDa).
A 1 hour primary incubation is recommended for this product.
FunctionPlays a role in the Notch signaling pathway. Activates Notch-1 and Notch-4.
Tissue specificityExpressed in vascular endothelium.
Sequence similaritiesContains 1 DSL domain.
Contains 8 EGF-like domains.
DomainThe Delta-Serrate-Lag2 (DSL) domain is required for binding to the Notch receptor.
modificationsUbiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation.
- Information by UniProt
- AOS6 antibody
- Delta 4 antibody
- delta 4 precursor antibody
ab183532 has been referenced in 2 publications.
- Zhao L et al. Oxymatrine Inhibits Transforming Growth Factor ß1 (TGF-ß1)-Induced Cardiac Fibroblast-to-Myofibroblast Transformation (FMT) by Mediating the Notch Signaling Pathway In Vitro. Med Sci Monit 24:6280-6288 (2018). PubMed: 30196308
- Ye X et al. Altered ratios of pro- and anti-angiogenic VEGF-A variants and pericyte expression of DLL4 disrupt vascular maturation in infantile haemangioma. J Pathol 239:139-51 (2016). IHC-P ; Human . PubMed: 26957058