Anti-DLL4 antibody (ab7280)

Rabbit polyclonal DLL4 antibody. Validated in WB, ELISA, IHC, ICC/IF and tested in Mouse, Human. Cited in 60 publication(s). Independently reviewed in 8 review(s).

Publishing research using ab7280? Please let us know so that we can cite the reference in this datasheet.

ab7280 has been referenced in 65 publications.

  • Zhang Y  et al. MicroRNA-30a as a candidate underlying sex-specific differences in neonatal hyperoxic lung injury: implications for BPD. Am J Physiol Lung Cell Mol Physiol 316:L144-L156 (2019). PubMed: 30382766
  • Pattanaik S  et al. Vascular Tissue Engineering Using Scaffold-Free Prevascular Endothelial-Fibroblast Constructs. Biores Open Access 8:1-15 (2019). PubMed: 30637179
  • McClements L  et al. FKBPL and its peptide derivatives inhibit endocrine therapy resistant cancer stem cells and breast cancer metastasis by downregulating DLL4 and Notch4. BMC Cancer 19:351 (2019). PubMed: 30975104
  • Wang P  et al. Shear stress promotes differentiation of stem cells from human exfoliated deciduous teeth into endothelial cells via the downstream pathway of VEGF-Notch signaling. Int J Mol Med 42:1827-1836 (2018). PubMed: 30015843
  • López-Arribillaga E  et al. Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells. Nat Commun 9:2992 (2018). PubMed: 30065304
  • Niderla-Bielinska J  et al. Pentoxifylline inhibits angiogenesis via decreasing Dll4 and Notch1 expression in mouse proepicardial explant cultures. Eur J Pharmacol 827:80-87 (2018). WB . PubMed: 29535000
  • Chattopadhyay A  et al. Treating the Intestine with Oral ApoA-I Mimetic Tg6F Reduces Tumor Burden in Mouse Models of Metastatic Lung Cancer. Sci Rep 8:9032 (2018). PubMed: 29899427
  • Jarad M  et al. Release of endothelial cell associated VEGFR2 during TGF-ß modulated angiogenesis in vitro. BMC Cell Biol 18:10 (2017). WB . PubMed: 28114883
  • Oon CE  et al. Role of Delta-like 4 in Jagged1-induced tumour angiogenesis and tumour growth. Oncotarget 8:40115-40131 (2017). ICC/IF . PubMed: 28445154
  • Zhang J  et al. Differential expression of the Notch1 receptor, and its ligands Dll1, Dll3 and Dll4 in distinct human pituitary adenoma subtypes. Oncol Lett 13:4533-4539 (2017). PubMed: 28599454
  • Xu L  et al. Different Angiogenic Potentials of Mesenchymal Stem Cells Derived from Umbilical Artery, Umbilical Vein, and Wharton's Jelly. Stem Cells Int 2017:3175748 (2017). PubMed: 28874910
  • Yang MH  et al. Anti-angiogenic effect of arsenic trioxide in lung cancer via inhibition of endothelial cell migration, proliferation and tube formation. Oncol Lett 14:3103-3109 (2017). PubMed: 28928847
  • Chen KY  et al. A Notch positive feedback in the intestinal stem cell niche is essential for stem cell self-renewal. Mol Syst Biol 13:927 (2017). WB . PubMed: 28455349
  • Wang J  et al. EGFL7 participates in regulating biological behavior of growth hormone-secreting pituitary adenomas via Notch2/DLL3 signaling pathway. Tumour Biol 39:1010428317706203 (2017). PubMed: 28705113
  • Fortini F  et al. Estrogen receptor ß-dependent Notch1 activation protects vascular endothelium against tumor necrosis factor a (TNFa)-induced apoptosis. J Biol Chem 292:18178-18191 (2017). PubMed: 28893903
  • Daley-Brown D  et al. Type II Endometrial Cancer Overexpresses NILCO: A Preliminary Evaluation. Dis Markers 2017:8248175 (2017). WB, IHC, Real Time PCR ; Human . PubMed: 28659656
  • Kim RK  et al. Radiation driven epithelial-mesenchymal transition is mediated by Notch signaling in breast cancer. Oncotarget 7:53430-53442 (2016). PubMed: 27462787
  • Lanier V  et al. Leptin-induced transphosphorylation of vascular endothelial growth factor receptor increases Notch and stimulates endothelial cell angiogenic transformation. Int J Biochem Cell Biol 79:139-150 (2016). PubMed: 27590851
  • Lv JY  et al. Deciphering the anti-angiogenic effect of endostatin/cyclophosphamide to normalize tumor micrangium through notch signaling pathway in colon cancer. World J Surg Oncol 14:10 (2016). WB, SDS-PAGE ; Mouse . PubMed: 26762567
  • Gerby B  et al. High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells. J Clin Invest 126:4569-4584 (2016). Mouse . PubMed: 27797342
  • Xiao Y  et al. Inhibition of cell proliferation and tumor growth of colorectal cancer by inhibitors of Wnt and Notch signaling pathways. Oncol Lett 12:3695-3700 (2016). WB . PubMed: 27900056
  • Surendran S  et al. Arterialization and anomalous vein wall remodeling in varicose veins is associated with upregulated FoxC2-Dll4 pathway. Lab Invest 96:399-408 (2016). PubMed: 26808710
  • Blancas AA  et al. Identifying Behavioral Phenotypes and Heterogeneity in Heart Valve Surface Endothelium. Cells Tissues Organs 201:268-76 (2016). PubMed: 27144771
  • Drouillard A  et al. DLL4 expression is a prognostic marker and may predict gemcitabine benefit in resected pancreatic cancer. Br J Cancer 115:1245-1252 (2016). PubMed: 27755532
  • Singh NK  et al. Cyclic AMP Response Element Binding Protein Mediates Pathological Retinal Neovascularization via Modulating DLL4-NOTCH1 Signaling. EBioMedicine 2:1767-84 (2015). PubMed: 26870802
  • Gopinathan G  et al. Interleukin-6 Stimulates Defective Angiogenesis. Cancer Res 75:3098-107 (2015). PubMed: 26081809
  • Minuzzo S  et al. DLL4 regulates NOTCH signaling and growth of T acute lymphoblastic leukemia cells in NOD/SCID mice. Carcinogenesis 36:115-21 (2015). PubMed: 25355291
  • Gama-Norton L  et al. Notch signal strength controls cell fate in the haemogenic endothelium. Nat Commun 6:8510 (2015). PubMed: 26465397
  • Talaber G  et al. ACTH controls thymocyte homeostasis independent of glucocorticoids. FASEB J 29:2526-34 (2015). PubMed: 25733567
  • Zhang JJ  et al. Bevacizumab modulates retinal pigment epithelial-to-mesenchymal transition via regulating Notch signaling. Int J Ophthalmol 8:245-9 (2015). PubMed: 25938035
  • Veliceasa D  et al. Therapeutic manipulation of angiogenesis with miR-27b. Vasc Cell 7:6 (2015). IHC-Fr ; Mouse . PubMed: 26161255
  • Paiva TF  et al. Angiogenesis-related protein expression in bevacizumab-treated metastatic colorectal cancer: NOTCH1 detrimental to overall survival. BMC Cancer 15:643 (2015). IHC-P ; Human . PubMed: 26394830
  • Hu GH  et al. Delta-like ligand 4 (Dll4) predicts the prognosis of clear cell renal cell carcinoma, and anti-Dll4 suppresses tumor growth in vivo. Int J Clin Exp Pathol 7:2143-52 (2014). WB, IHC-P ; Human . PubMed: 24966922
  • Chung B  et al. Engineering the human thymic microenvironment to support thymopoiesis in vivo. Stem Cells 32:2386-96 (2014). Human . PubMed: 24801626
  • Wang W  et al. Delta-like ligand 4: A predictor of poor prognosis in clear cell renal cell carcinoma. Oncol Lett 8:2627-2633 (2014). WB, IHC ; Human . PubMed: 25364440
  • Otti GR  et al. Notch2 controls prolactin and insulin-like growth factor binding protein-1 expression in decidualizing human stromal cells of early pregnancy. PLoS One 9:e112723 (2014). IHC-P, WB ; Human . PubMed: 25397403
  • Murta D  et al. In vivo notch signaling blockade induces abnormal spermatogenesis in the mouse. PLoS One 9:e113365 (2014). IHC ; Mouse . PubMed: 25412258
  • Zhang C  et al. Inhibition of endothelial ERK signalling by Smad1/5 is essential for haematopoietic stem cell emergence. Nat Commun 5:3431 (2014). PubMed: 24614941
  • Zhang S  et al. Targeting Met and Notch in the Lfng-deficient, Met-amplified triple-negative breast cancer. Cancer Biol Ther 15:633-42 (2014). PubMed: 24556651
  • Haider S  et al. Notch signaling plays a critical role in motility and differentiation of human first-trimester cytotrophoblasts. Endocrinology 155:263-74 (2014). PubMed: 24189144
  • Qiu XX  et al. High delta-like ligand 4 (DLL4) is correlated with peritumoral brain edema and predicts poor prognosis in primary glioblastoma. Medicine (Baltimore) 93:e57 (2014). IHC . PubMed: 25121357
  • Maeda A  et al. Influence of vascular endothelial growth factor single nucleotide polymorphisms on non-small cell lung cancer tumor angiogenesis. Oncol Rep 29:39-44 (2013). IHC . PubMed: 23064377
  • Harrison H  et al. Oestrogen increases the activity of oestrogen receptor negative breast cancer stem cells through paracrine EGFR and Notch signalling. Breast Cancer Res 15:R21 (2013). WB ; Human . PubMed: 23497505
  • Bazan-Peregrino M  et al. Combining virotherapy and angiotherapy for the treatment of breast cancer. Cancer Gene Ther 20:461-8 (2013). WB . PubMed: 23846253
  • Murta D  et al. Dynamics of Notch pathway expression during mouse testis post-natal development and along the spermatogenic cycle. PLoS One 8:e72767 (2013). IHC-P ; Mouse . PubMed: 24015274
  • Caliceti C  et al. 17ß-estradiol enhances signalling mediated by VEGF-A-delta-like ligand 4-notch1 axis in human endothelial cells. PLoS One 8:e71440 (2013). PubMed: 23967210
  • Fang Y  et al. Association of Dll4/notch and HIF-1a -VEGF signaling in the angiogenesis of missed abortion. PLoS One 8:e70667 (2013). IHC-P ; Human . PubMed: 23950980
  • Furukawa S  et al. The miR-1-NOTCH3-Asef pathway is important for colorectal tumor cell migration. PLoS One 8:e80609 (2013). WB ; Human . PubMed: 24244701
  • Zhao WX  et al. Expression of Notch Family Proteins in Placentas From Patients With Early-Onset Severe Preeclampsia. Reprod Sci N/A:N/A (2013). Human . PubMed: 24336671
  • Sundlisaeter E  et al. The alarmin IL-33 is a notch target in quiescent endothelial cells. Am J Pathol 181:1099-111 (2012). IHC-P ; Human . PubMed: 22809957
  • Camelo S  et al. Delta-like 4 inhibits choroidal neovascularization despite opposing effects on vascular endothelium and macrophages. Angiogenesis 15:609-22 (2012). IHC . PubMed: 22869002
  • Cook N  et al. Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma. J Exp Med 209:437-44 (2012). Mouse . PubMed: 22351932
  • Meehan B  et al. Age-related properties of the tumour vasculature in renal cell carcinoma. BJU Int 107:416-24 (2011). PubMed: 20804487
  • Donnem T  et al. Prognostic impact of Notch ligands and receptors in nonsmall cell lung cancer: coexpression of Notch-1 and vascular endothelial growth factor-A predicts poor survival. Cancer 116:5676-85 (2010). PubMed: 20737536
  • Schadler KL  et al. Delta-like ligand 4 plays a critical role in pericyte/vascular smooth muscle cell formation during vasculogenesis and tumor vessel expansion in Ewing's sarcoma. Clin Cancer Res 16:848-56 (2010). IHC-P ; Human . PubMed: 20103680
  • Sheldon H  et al. New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes. Blood 116:2385-94 (2010). WB ; Human . PubMed: 20558614
  • Lasagni L  et al. Notch activation differentially regulates renal progenitors proliferation and differentiation toward the podocyte lineage in glomerular disorders. Stem Cells 28:1674-85 (2010). ICC/IF ; Human . PubMed: 20680961
  • Pistollato F  et al. Interaction of Hypoxia-Inducible Factor-1a and Notch Signaling Regulates Medulloblastoma Precursor Proliferation and Fate. Stem Cells 28:1918-1929 (2010). WB, ICC/IF ; Human . PubMed: 20827750
  • Sörensen I  et al. DLL1-mediated Notch activation regulates endothelial identity in mouse fetal arteries. Blood 113:5680-8 (2009). WB, IHC-P ; Mouse . PubMed: 19144989
  • Xiong YQ  et al. Human hepatocellular carcinoma tumor-derived endothelial cells manifest increased angiogenesis capability and drug resistance compared with normal endothelial cells. Clin Cancer Res 15:4838-46 (2009). WB ; Human . PubMed: 19638466
  • ZhuGe Q  et al. Notch-1 signalling is activated in brain arteriovenous malformations in humans. Brain 132:3231-41 (2009). PubMed: 19812212
  • Liu Z  et al. Epithelial transformation by KLF4 requires Notch1 but not canonical Notch1 signaling. Cancer Biol Ther 8:1840-51 (2009). PubMed: 19717984
  • Lahmar M  et al. Distinct effects of the soluble versus membrane-bound forms of the notch ligand delta-4 on human CD34+CD38low cell expansion and differentiation. Stem Cells 26:621-9 (2008). WB ; Human . PubMed: 18055448
  • Ivey KN  et al. MicroRNA regulation of cell lineages in mouse and human embryonic stem cells. Cell Stem Cell 2:219-29 (2008). ICC/IF ; Mouse . PubMed: 18371447
  • Mazella J  et al. Expression of Delta-like protein 4 in the human endometrium. Endocrinology 149:15-9 (2008). PubMed: 17916635

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