Product nameAnti-DLX3 antibody
See all DLX3 primary antibodies
DescriptionRabbit polyclonal to DLX3
Tested applicationsSuitable for: WB, ELISA, ChIP, CHIPseqmore details
Species reactivityReacts with: Mouse, Human
Predicted to work with: Rat, Sheep, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Saccharomyces cerevisiae, Chimpanzee, Spider monkey
- Purchase matching WB positive control:Recombinant Human DLX3 protein
- Transfected 293T cell lysate
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.09% Sodium azide
Constituents: 2% Sucrose, PBS
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab66390 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 1.25 µg/ml. Detects a band of approximately 40 kDa (predicted molecular weight: 32 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.|
|ChIP||Use at an assay dependent concentration. PubMed: 22351765|
|CHIPseq||Use at an assay dependent concentration. PubMed: 22351765|
FunctionLikely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.
Involvement in diseaseDefects in DLX3 are a cause of trichodentoosseous syndrome (TDO) [MIM:190320]. TDO is an autosomal dominant syndrome characterized by enamel hypoplasia and hypocalcification with associated strikingly curly hair.
Defects in DLX3 are the cause of amelogenesis imperfecta type 4 (AI4) [MIM:104510]; also known as amelogenesis imperfecta hypomaturation-hypoplastic type with taurodontism. AI4 is an autosomal dominant defect of enamel formation associated with enlarged pulp chambers.
Sequence similaritiesBelongs to the distal-less homeobox family.
Contains 1 homeobox DNA-binding domain.
- Information by UniProt
- AI4 antibody
- Distal less homeo box 3 antibody
- DLX 3 antibody
Anti-DLX3 antibody (ab66390) at 1.25 µg/ml + Transfected 293T cell lysate at 10 µg
HRP conjugated anti-Rabbit IgG at 1/50000 dilution
Predicted band size: 32 kDa
Observed band size: 40 kDa why is the actual band size different from the predicted?
This product has been referenced in:
- Dunn-Fletcher CE et al. Anthropoid primate-specific retroviral element THE1B controls expression of CRH in placenta and alters gestation length. PLoS Biol 16:e2006337 (2018). Read more (PubMed: 30231016) »
- Li S & Roberson MS DLX3 interacts with GCM1 and inhibits its transactivation-stimulating activity in a homeodomain-dependent manner in human trophoblast-derived cells. Sci Rep 7:2009 (2017). Read more (PubMed: 28515447) »