Product nameDMAPT, NF-kappaB inhibitor
Biological descriptionNF-κB inhibitor. Reduces NF-κB DNA binding. Shows antiproliferative effects (IC50 = 5-10 μM). Parthenolide (ab120849) analog. Epigenetic modulator, functions NFκB-dependently and independently. Generates ROS and shows antitumor effects in vivo. Orally active.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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This product has been referenced in:
- Nakshatri H et al. NF-?B-dependent and -independent epigenetic modulation using the novel anti-cancer agent DMAPT. Cell Death Dis 6:e1608 (2015). Read more (PubMed: 25611383) »
- Burnett RM et al. Organ-specific adaptive signaling pathway activation in metastatic breast cancer cells. Oncotarget 6:12682-96 (2015). Read more (PubMed: 25926557) »
- Song JM et al. Dimethylaminoparthenolide, a water soluble parthenolide, suppresses lung tumorigenesis through down-regulating the STAT3 signaling pathway. Curr Cancer Drug Targets 14:59-69 (2014). Read more (PubMed: 24200081) »