Rabbit monoclonal [EPR7519(2)] to DNA Polymerase lambda
WBmore details Unsuitable for:
Flow Cyt,ICC/IF,IHC-P or IP
Mouse, Rat, Human
Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human DNA Polymerase lambda aa 550 to the C-terminus (Cysteine residue). The exact sequence is proprietary. Database link: Q9UGP5
HepG2, HeLa and 293T cell lysates.
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents
This product is a recombinant rabbit monoclonal antibody.
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/1000 - 1/10000. Detects a band of approximately 68 kDa (predicted molecular weight: 63 kDa).
Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.
Repair polymerase. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Has both DNA polymerase and terminal transferase activities. Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
Expressed in a number of tissues. Abundant in testis.
Belongs to the DNA polymerase type-X family. Contains 1 BRCT domain.
Phosphorylated upon DNA damage, probably by ATM or ATR.