Overview

  • Product name
    Anti-DNAJC3 antibody
    See all DNAJC3 primary antibodies
  • Description
    Rabbit polyclonal to DNAJC3
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Pig
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 270-492 of Human DNAJC3 (UniProt Q13217).

  • Positive control
    • 293T, A431, H1299, HeLa, HepG2, MOLT4 and Raji cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab154714 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 58 kDa.

Target

  • Function
    Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity.
  • Tissue specificity
    Widely expressed with high level in the pancreas and testis. Also expressed in cell lines with different levels.
  • Sequence similarities
    Contains 1 J domain.
    Contains 9 TPR repeats.
  • Domain
    The J domain mediates interaction with HSPA8.
  • Cellular localization
    Endoplasmic reticulum.
  • Information by UniProt
  • Database links
    see all
  • Alternative names
    • DnaJ (Hsp40) homolog subfamily C member 3 antibody
    • DnaJ homolog subfamily C member 3 antibody
    • DNAJC3 antibody
    • DNJC3_HUMAN antibody
    • double-stranded RNA-activated protein kinase inhibitor antibody
    • Endoplasmic reticulum DnaJ protein 6 antibody
    • ERdj6 antibody
    • HP58 antibody
    • Interferon induced, double stranded RNA activated protein kinase inhibitor antibody
    • Interferon-induced antibody
    • P58 antibody
    • p58 ipk antibody
    • P58IPK antibody
    • PRKRI antibody
    • Protein kinase inhibitor of 58 kDa antibody
    • Protein kinase inhibitor p58 antibody
    • Protein kinase interferon inducible double stranded RNA dependent inhibitor antibody
    see all

Images

  • Western blot - Anti-DNAJC3 antibody (ab154714)
    Western blot - Anti-DNAJC3 antibody (ab154714)
    All lanes : Anti-DNAJC3 antibody (ab154714) at 1/1000 dilution

    Lane 1 : A431 whole cell lysate
    Lane 2 : H1299 whole cell lysate
    Lane 3 : HeLa whole cell lysate
    Lane 4 : MOLT4 whole cell lysate
    Lane 5 : Raji whole cell lysate

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 58 kDa



    7.5% SDS PAGE

References

ab154714 has not yet been referenced specifically in any publications.

Publishing research using ab154714? Please let us know so that we can cite the reference in this datasheet.

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