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  1. Link

    dnase-gamma-antibody-ab152118.pdf

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Cell Biology Apoptosis Nucleus DNAses
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Anti-DNase gamma antibody (ab152118)

  • Datasheet
  • SDS
Submit a review Submit a question References (1)

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Immunocytochemistry/ Immunofluorescence - Anti-DNase gamma antibody (ab152118)
  • Immunocytochemistry/ Immunofluorescence - Anti-DNase gamma antibody (ab152118)
  • Immunocytochemistry/ Immunofluorescence - Anti-DNase gamma antibody (ab152118)
  • Immunocytochemistry/ Immunofluorescence - Anti-DNase gamma antibody (ab152118)
  • Immunocytochemistry/ Immunofluorescence - Anti-DNase gamma antibody (ab152118)
  • Western blot - Anti-DNase gamma antibody (ab152118)
  • Immunocytochemistry/ Immunofluorescence - Anti-DNase gamma antibody (ab152118)

Key features and details

  • Rabbit polyclonal to DNase gamma
  • Suitable for: WB, ICC/IF
  • Reacts with: Human
  • Isotype: IgG

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Primary
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Anti-DNase I antibody (ab113241)
Secondary
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Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
Protein
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Recombinant Human DNase gamma protein (Tagged) (ab238220)

View more associated products

Overview

  • Product name

    Anti-DNase gamma antibody
    See all DNase gamma primary antibodies
  • Description

    Rabbit polyclonal to DNase gamma
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, ICC/IFmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 115-305 of Human DNase gamma (UniProt; Q13609).

  • Positive control

    • A549, HeLa, HepG2 and HCT116 whole cell lysates; HeLa cells.
  • General notes

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.00
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol (glycerin, glycerine)
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Cell Biology
    • Apoptosis
    • Nucleus
    • DNAses
    • Epigenetics and Nuclear Signaling
    • Cell cycle
    • Apoptosis
    • Nuclear
    • Metabolism
    • Pathways and Processes
    • Metabolism processes
    • Apoptosis
    • Cancer
    • Cell Death
    • Apoptosis
    • Nucleus
    • DNAses
    • Cancer
    • Cell Death
    • Apoptosis
    • Metabolism

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
  • Positive Controls

    • HeLa whole cell lysate (ab29545)
    • A549 whole cell lysate (ab7910)
  • Recombinant Protein

    • Recombinant Human DNase gamma protein (Tagged) (ab238220)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab152118 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
1/500 - 1/3000. Predicted molecular weight: 36 kDa.
ICC/IF
1/100 - 1/1000.
Notes
WB
1/500 - 1/3000. Predicted molecular weight: 36 kDa.
ICC/IF
1/100 - 1/1000.

Target

  • Function

    Has DNA hydrolytic activity. Does not bind to actin. Cleaves chromatin DNA to nucleosomal units.
  • Tissue specificity

    Liver and spleen.
  • Sequence similarities

    Belongs to the DNase I family.
  • Cellular localization

    Nucleus. May first pass through the ER membrane before being imported in the nucleus.
  • Target information above from: UniProt accession Q13609 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 1776 Human
    • Omim: 602244 Human
    • SwissProt: Q13609 Human
    • Unigene: 476453 Human
    • Alternative names

      • Deoxyribonuclease gamma antibody
      • Deoxyribonuclease I like 3 antibody
      • Deoxyribonuclease I like III antibody
      • Deoxyribonuclease I-like 3 antibody
      • DHP 2 antibody
      • DHP2 antibody
      • DNAS1L3 antibody
      • DNase gamma antibody
      • DNase I homolog protein 2 antibody
      • DNase I homolog protein DHP2 antibody
      • DNase I like 3 antibody
      • DNase I-like 3 antibody
      • DNASE1L3 antibody
      • DNSL3_HUMAN antibody
      • Liver and spleen DNase antibody
      • LS DNase antibody
      • LS-DNase antibody
      • LSD antibody
      • SLEB 16 antibody
      • SLEB16 antibody
      see all

    Images

    • Immunocytochemistry/ Immunofluorescence - Anti-DNase gamma antibody (ab152118)
      Immunocytochemistry/ Immunofluorescence - Anti-DNase gamma antibody (ab152118)
    • Immunocytochemistry/ Immunofluorescence - Anti-DNase gamma antibody (ab152118)
      Immunocytochemistry/ Immunofluorescence - Anti-DNase gamma antibody (ab152118)
    • Immunocytochemistry/ Immunofluorescence - Anti-DNase gamma antibody (ab152118)
      Immunocytochemistry/ Immunofluorescence - Anti-DNase gamma antibody (ab152118)
    • Immunocytochemistry/ Immunofluorescence - Anti-DNase gamma antibody (ab152118)
      Immunocytochemistry/ Immunofluorescence - Anti-DNase gamma antibody (ab152118)
    • Immunocytochemistry/ Immunofluorescence - Anti-DNase gamma antibody (ab152118)
      Immunocytochemistry/ Immunofluorescence - Anti-DNase gamma antibody (ab152118)
    • Western blot - Anti-DNase gamma antibody (ab152118)
      Western blot - Anti-DNase gamma antibody (ab152118)
      Anti-DNase gamma antibody (ab152118) at 1/1000 dilution + HCT116 whole cell lysate at 30 µg

      Predicted band size: 36 kDa



      10% SDS PAGE
    • Immunocytochemistry/ Immunofluorescence - Anti-DNase gamma antibody (ab152118)
      Immunocytochemistry/ Immunofluorescence - Anti-DNase gamma antibody (ab152118)
      Immunofluorescent analysis of paraformaldehyde-fixed HeLa cells, labeling DNase gamma with ab152118 at 1/200 dilution. Lower image shows cells co-stained with Hoechst 33342.

    Protocols

    • Western blot protocols
    • Immunocytochemistry & immunofluorescence protocols

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (1)

    Publishing research using ab152118? Please let us know so that we can cite the reference in this datasheet.

    ab152118 has been referenced in 1 publication.

    • Lazzaretto B & Fadeel B Intra- and Extracellular Degradation of Neutrophil Extracellular Traps by Macrophages and Dendritic Cells. J Immunol 203:2276-2290 (2019). PubMed: 31519860

    Customer reviews and Q&As

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