Anti-Dnmt1 antibody [60B1220.1] - ChIP Grade (ab13537)

Mouse monoclonal Dnmt1 antibody [60B1220.1]. Validated in WB, IP, IHC, Flow Cyt, ChIP and tested in Mouse, Rat, Human, Zebrafish. Cited in 81 publication(s). Independently reviewed in 22 review(s).

Publishing research using ab13537? Please let us know so that we can cite the reference in this datasheet.

ab13537 has been referenced in 101 publications.

  • Mishra M & Kowluru RA DNA Methylation-a Potential Source of Mitochondria DNA Base Mismatch in the Development of Diabetic Retinopathy. Mol Neurobiol 56:88-101 (2019). PubMed: 29679259
  • Jin J  et al. Methylation-associated silencing of miR-128 promotes the development of esophageal cancer by targeting COX-2 in areas with a high incidence of esophageal cancer. Int J Oncol 54:644-654 (2019). PubMed: 30535495
  • Liu YR  et al. Long noncoding RNA MEG3 regulates rheumatoid arthritis by targeting NLRC5. J Cell Physiol N/A:N/A (2019). PubMed: 30644097
  • Lin K  et al. Long noncoding RNA LINC00261 induces chemosensitization to 5-fluorouracil by mediating methylation-dependent repression of DPYD in human esophageal cancer. FASEB J 33:1972-1988 (2019). PubMed: 30226808
  • Wu R  et al. Downregulation of KLF13 through DNMT1-mediated hypermethylation promotes glioma cell proliferation and invasion. Onco Targets Ther 12:1509-1520 (2019). PubMed: 30863117
  • Li GQ  et al. MALAT1-driven inhibition of Wnt signal impedes proliferation and inflammation in fibroblast-like synoviocytes through CTNNB1 promoter methylation in rheumatoid arthritis. Hum Gene Ther N/A:N/A (2019). PubMed: 30909750
  • Zhang J  et al. Excessive miR-25-3p maturation via N6-methyladenosine stimulated by cigarette smoke promotes pancreatic cancer progression. Nat Commun 10:1858 (2019). PubMed: 31015415
  • Chen JL  et al. Overexpression of long noncoding RNA LINC01419 in esophageal squamous cell carcinoma and its relation to the sensitivity to 5-fluorouracil by mediating GSTP1 methylation. Ther Adv Med Oncol 11:1758835919838958 (2019). PubMed: 31019568
  • Mudersbach T  et al. Epigenetic control of the angiotensin-converting enzyme in endothelial cells during inflammation. PLoS One 14:e0216218 (2019). PubMed: 31042763
  • He Y  et al. DNA methylation regulates a-smooth muscle actin expression during cardiac fibroblast differentiation. J Cell Physiol 234:7174-7185 (2019). PubMed: 30362530
  • Wang B  et al. krCRISPR: an easy and efficient strategy for generating conditional knockout of essential genes in cells. J Biol Eng 13:35 (2019). PubMed: 31049076
  • Xu X  et al. The long non-coding RNA Linc-GALH promotes hepatocellular carcinoma metastasis via epigenetically regulating Gankyrin. Cell Death Dis 10:86 (2019). PubMed: 30692513
  • Wang M  et al. Activation of PAR4 Upregulates p16 through Inhibition of DNMT1 and HDAC2 Expression via MAPK Signals in Esophageal Squamous Cell Carcinoma Cells. J Immunol Res 2018:4735752 (2018). PubMed: 30363984
  • Ibrahim ML  et al. Myeloid-Derived Suppressor Cells Produce IL-10 to Elicit DNMT3b-Dependent IRF8 Silencing to Promote Colitis-Associated Colon Tumorigenesis. Cell Rep 25:3036-3046.e6 (2018). PubMed: 30540937
  • Zhou J  et al. Linc00441 interacts with DNMT1 to regulate RB1 gene methylation and expression in gastric cancer. Oncotarget 9:37471-37479 (2018). PubMed: 30680063
  • Duraisamy AJ  et al. Epigenetics and Regulation of Oxidative Stress in Diabetic Retinopathy. Invest Ophthalmol Vis Sci 59:4831-4840 (2018). PubMed: 30347077
  • Zhang B  et al. NCOA3 Loss Disrupts Molecular Signature of Chondrocytes and Promotes Posttraumatic Osteoarthritis Progression. Cell Physiol Biochem 49:2396-2413 (2018). PubMed: 30261507
  • Tanwar V  et al. Preconception Exposure to Fine Particulate Matter Leads to Cardiac Dysfunction in Adult Male Offspring. J Am Heart Assoc 7:e010797 (2018). PubMed: 30561255
  • Ji S  et al. Cranial irradiation inhibits hippocampal neurogenesis via DNMT1 and DNMT3A. Oncol Lett 15:2899-2904 (2018). PubMed: 29435016
  • Peng J  et al. The detrimental effects of glucocorticoids exposure during pregnancy on offspring's cardiac functions mediated by hypermethylation of bone morphogenetic protein-4. Cell Death Dis 9:834 (2018). PubMed: 30082698
  • Wu F  et al. Oct4 regulates DNA methyltransferase 1 transcription by direct binding of the regulatory element. Cell Mol Biol Lett 23:39 (2018). PubMed: 30140294
  • Santamarina AB  et al. Supplementation of Juçara Berry (Euterpe edulis Mart.) Modulates Epigenetic Markers in Monocytes from Obese Adults: A Double-Blind Randomized Trial. Nutrients 10:N/A (2018). PubMed: 30513988
  • Zhang X  et al. The inhibition of UBC13 expression and blockage of the DNMT1-CHFR-Aurora A pathway contribute to paclitaxel resistance in ovarian cancer. Cell Death Dis 9:93 (2018). PubMed: 29367628
  • Zhao M  et al. IL-6/STAT3 pathway induced deficiency of RFX1 contributes to Th17-dependent autoimmune diseases via epigenetic regulation. Nat Commun 9:583 (2018). ChIP . PubMed: 29422534
  • Kovalchuk A  et al. Adverse effects of paternal chemotherapy exposure on the progeny brain: intergenerational chemobrain. Oncotarget 9:10069-10082 (2018). WB . PubMed: 29515791
  • Fan Y  et al. Mechanism of salvianolic acid B neuroprotection against ischemia/reperfusion induced cerebral injury. Brain Res 1679:125-133 (2018). PubMed: 29180227
  • Zhang S  et al. Up-regulation of microRNA-203 in influenza A virus infection inhibits viral replication by targeting DR1. Sci Rep 8:6797 (2018). WB . PubMed: 29717211
  • George AK  et al. Exercise Mitigates Alcohol Induced Endoplasmic Reticulum Stress Mediated Cognitive Impairment through ATF6-Herp Signaling. Sci Rep 8:5158 (2018). PubMed: 29581524
  • Pan XY  et al. DNA Methylation of PTGIS Enhances Hepatic Stellate Cells Activation and Liver Fibrogenesis. Front Pharmacol 9:553 (2018). PubMed: 29892223
  • Liu X  et al. Protein arginine methyltransferase 5-mediated epigenetic silencing of IRX1 contributes to tumorigenicity and metastasis of gastric cancer. Biochim Biophys Acta N/A:N/A (2018). ChIP ; Human . PubMed: 29802960
  • Li J  et al. Heat Shock Factor 1 Epigenetically Stimulates Glutaminase-1-Dependent mTOR Activation to Promote Colorectal Carcinogenesis. Mol Ther 26:1828-1839 (2018). PubMed: 29730197
  • Soni P  et al. Aflatoxin B1 induced multiple epigenetic modulators in human epithelial cell lines. Toxicon 151:119-128 (2018). PubMed: 30006306
  • Teng Y  et al. DNMT1 ablation suppresses tumorigenesis by inhibiting the self-renewal of esophageal cancer stem cells. Oncotarget 9:18896-18907 (2018). PubMed: 29721170
  • Li Y  et al. A novel epigenetic AML1-ETO/THAP10/miR-383 mini-circuitry contributes to t(8;21) leukaemogenesis. EMBO Mol Med 9:933-949 (2017). WB . PubMed: 28539478
  • Yang C  et al. Regulation of RIP3 by the transcription factor Sp1 and the epigenetic regulator UHRF1 modulates cancer cell necroptosis. Cell Death Dis 8:e3084 (2017). PubMed: 28981102
  • Kowluru RA & Shan Y Role of oxidative stress in epigenetic modification of MMP-9 promoter in the development of diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol 255:955-962 (2017). PubMed: 28124145
  • Dumasia K  et al. Estrogen signaling, through estrogen receptor ß, regulates DNA methylation and its machinery in male germ line in adult rats. Epigenetics 12:476-483 (2017). PubMed: 28362134
  • Dong J  et al. Epigenetic silencing of microRNA-137 enhances ASCT2 expression and tumor glutamine metabolism. Oncogenesis 6:e356 (2017). ChIP . PubMed: 28692032
  • Mou H  et al. Genetic disruption of oncogenic Kras sensitizes lung cancer cells to Fas receptor-mediated apoptosis. Proc Natl Acad Sci U S A 114:3648-3653 (2017). ChIP . PubMed: 28320962
  • Duraisamy AJ  et al. Crosstalk Between Histone and DNA Methylation in Regulation of Retinal Matrix Metalloproteinase-9 in Diabetes. Invest Ophthalmol Vis Sci 58:6440-6448 (2017). PubMed: 29261844
  • Xu Y  et al. miRNA-148a regulates the expression of the estrogen receptor through DNMT1-mediated DNA methylation in breast cancer cells. Oncol Lett 14:4736-4740 (2017). PubMed: 29085474
  • Wang J  et al. Notable roles of EZH2 and DNMT1 in epigenetic dormancy of the SHP1 gene during the progression of chronic myeloid leukaemia. Oncol Lett 13:4979-4985 (2017). PubMed: 28599500
  • Li Y  et al. Combinatorial bioactive botanicals re-sensitize tamoxifen treatment in ER-negative breast cancer via epigenetic reactivation of ERa expression. Sci Rep 7:9345 (2017). PubMed: 28839265
  • Kovalchuk A  et al. Chemo brain or tumor brain - that is the question: the presence of extracranial tumors profoundly affects molecular processes in the prefrontal cortex of TumorGraft mice. Aging (Albany NY) 9:1660-1676 (2017). WB ; Mouse . PubMed: 28758896
  • Chen S  et al. Histone H2B monoubiquitination is a critical epigenetic switch for the regulation of autophagy. Nucleic Acids Res 45:1144-1158 (2017). WB ; Human . PubMed: 28180298
  • Zhang D  et al. Non-CpG methylation by DNMT3B facilitates REST binding and gene silencing in developing mouse hearts. Nucleic Acids Res 45:3102-3115 (2017). WB ; Mouse . PubMed: 27956497
  • Saini SK  et al. DNA Methyltransferase1 (DNMT1) Isoform3 methylates mitochondrial genome and modulates its biology. Sci Rep 7:1525 (2017). WB ; Human . PubMed: 28484249
  • Solly F  et al. An miRNA-DNMT1 Axis Is Involved in Azacitidine Resistance and Predicts Survival in Higher-Risk Myelodysplastic Syndrome and Low Blast Count Acute Myeloid Leukemia. Clin Cancer Res 23:3025-3034 (2017). PubMed: 27881579
  • Liu R  et al. Dnmt1 regulates the myogenic lineage specification of muscle stem cells. Sci Rep 6:35355 (2016). WB ; Mouse . PubMed: 27752090
  • Mishra M & Kowluru RA The Role of DNA Methylation in the Metabolic Memory Phenomenon Associated With the Continued Progression of Diabetic Retinopathy. Invest Ophthalmol Vis Sci 57:5748-5757 (2016). IHC ; Human . PubMed: 27787562
  • Chen S  et al. Histone H2B monoubiquitination is a critical epigenetic switch for the regulation of autophagy. Nucleic Acids Res N/A:N/A (2016). WB ; Human . PubMed: 27789696
  • Ko E  et al. The TERT promoter SNP rs2853669 decreases E2F1 transcription factor binding and increases mortality and recurrence risks in liver cancer. Oncotarget 7:684-99 (2016). IF . PubMed: 26575952
  • Huang S  et al. Epigenetic Silencing of Eyes Absent 4 Gene by Acute Myeloid Leukemia 1-Eight-twenty-one Oncoprotein Contributes to Leukemogenesis in t(8;21) Acute Myeloid Leukemia. Chin Med J (Engl) 129:1355-62 (2016). ChIP . PubMed: 27231175
  • Cao W  et al. CXXC finger protein 1 is critical for T-cell intrathymic development through regulating H3K4 trimethylation. Nat Commun 7:11687 (2016). PubMed: 27210293
  • Chaturvedi P & Tyagi SC Epigenetic silencing of TIMP4 in heart failure. J Cell Mol Med 20:2089-2101 (2016). WB . PubMed: 27396717
  • Li C  et al. MEK inhibitor PD0325901 and vitamin C synergistically induce hypomethylation of mouse embryonic stem cells. Oncotarget 7:39730-39739 (2016). PubMed: 27213595
  • Koh HB  et al. Transforming Growth Factor-ß1 Increases DNA Methyltransferase 1 and 3a Expression through Distinct Post-transcriptional Mechanisms in Lung Fibroblasts. J Biol Chem 291:19287-98 (2016). PubMed: 27405758
  • Kowluru RA  et al. Dynamic DNA methylation of matrix metalloproteinase-9 in the development of diabetic retinopathy. Lab Invest 96:1040-9 (2016). PubMed: 27454437
  • Yang AN  et al. High-methionine diets accelerate atherosclerosis by HHcy-mediated FABP4 gene demethylation pathway via DNMT1 in ApoE(-/-) mice. FEBS Lett 589:3998-4009 (2015). WB . PubMed: 26606905
  • Kim AY  et al. Obesity-induced DNA hypermethylation of the adiponectin gene mediates insulin resistance. Nat Commun 6:7585 (2015). WB ; Mouse . PubMed: 26139044
  • Cheng PF  et al. Methylation-dependent SOX9 expression mediates invasion in human melanoma cells and is a negative prognostic factor in advanced melanoma. Genome Biol 16:42 (2015). WB . PubMed: 25885555
  • Mishra M & Kowluru RA Epigenetic Modification of Mitochondrial DNA in the Development of Diabetic Retinopathy. Invest Ophthalmol Vis Sci 56:5133-42 (2015). PubMed: 26241401
  • Xiao X  et al. Epigenetic repression of Krüppel-like factor 4 through Dnmt1 contributes to EMT in renal fibrosis. Int J Mol Med 35:1596-602 (2015). ChIP ; Human . PubMed: 25892014
  • Peng D  et al. Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy. Nature 527:249-53 (2015). WB ; Human . PubMed: 26503055
  • Chalertpet K  et al. Human papillomavirus type 16 E7 oncoprotein mediates CCNA1 promoter methylation. Cancer Sci 106:1333-40 (2015). ChIP, WB ; Human . PubMed: 26250467
  • Cacan E  et al. Inhibition of HDAC1 and DNMT1 modulate RGS10 expression and decrease ovarian cancer chemoresistance. PLoS One 9:e87455 (2014). Human . PubMed: 24475290
  • Liu B  et al. PIAS1 regulates breast tumorigenesis through selective epigenetic gene silencing. PLoS One 9:e89464 (2014). ChIP . PubMed: 24586797
  • Shen W  et al. Epigenetic modification of the leptin promoter in diet-induced obese mice and the effects of N-3 polyunsaturated Fatty acids. Sci Rep 4:5282 (2014). ChIP ; Mouse . PubMed: 24923522
  • Bhatnagar S  et al. Genetic and pharmacological reactivation of the mammalian inactive X chromosome. Proc Natl Acad Sci U S A 111:12591-8 (2014). PubMed: 25136103
  • Pellacani D  et al. DNA hypermethylation in prostate cancer is a consequence of aberrant epithelial differentiation and hyperproliferation. Cell Death Differ 21:761-73 (2014). WB . PubMed: 24464224
  • Xie Q  et al. Epigenetic silencing of SFRP1 and SFRP5 by hepatitis B virus X protein enhances hepatoma cell tumorigenicity through Wnt signaling pathway. Int J Cancer 135:635-46 (2014). PubMed: 24374650
  • Lin WC  et al. The role of Sp1 and EZH2 in the regulation of LMX1A in cervical cancer cells. Biochim Biophys Acta 1833:3206-3217 (2013). PubMed: 24018208
  • Arabsolghar R  et al. Mutant p53 binds to estrogen receptor negative promoter via DNMT1 and HDAC1 in MDA-MB-468 breast cancer cells. Mol Biol Rep 40:2617-25 (2013). PubMed: 23242655
  • Shamma A  et al. ATM mediates pRB function to control DNMT1 protein stability and DNA methylation. Mol Cell Biol 33:3113-24 (2013). PubMed: 23754744
  • Kiianitsa K & Maizels N A rapid and sensitive assay for DNA-protein covalent complexes in living cells. Nucleic Acids Res 41:e104 (2013). WB ; Human . PubMed: 23519618
  • Wong YF  et al. Prolonged treatment with DNMT inhibitors induces distinct effects in promoters and gene-bodies. PLoS One 8:e71099 (2013). WB ; Human . PubMed: 23940695
  • Morano A  et al. Targeted DNA methylation by homology-directed repair in mammalian cells. Transcription reshapes methylation on the repaired gene. Nucleic Acids Res N/A:N/A (2013). ChIP ; Human . PubMed: 24137009
  • Di Ruscio A  et al. DNMT1-interacting RNAs block gene-specific DNA methylation. Nature 503:371-6 (2013). IP . PubMed: 24107992
  • Sidler C  et al. Immunosenescence is associated with altered gene expression and epigenetic regulation in primary and secondary immune organs. Front Genet 4:211 (2013). Rat . PubMed: 24151501
  • Armstrong VL  et al. Expression of DNA Methyltransferases Is Influenced by Growth Hormone in the Long-Living Ames Dwarf Mouse In Vivo and In Vitro. J Gerontol A Biol Sci Med Sci N/A:N/A (2013). Mouse . PubMed: 24201695
  • Zhang B  et al. The p16-specific reactivation and inhibition of cell migration through demethylation of CpG islands by engineered transcription factors. Hum Gene Ther 23:1071-81 (2012). ChIP ; Human . PubMed: 22738793
  • Chen M  et al. DNA methyltransferase inhibitor, zebularine, delays tumor growth and induces apoptosis in a genetically engineered mouse model of breast cancer. Mol Cancer Ther 11:370-82 (2012). WB . PubMed: 22203734
  • Chavali V  et al. MicroRNA-133a regulates DNA methylation in diabetic cardiomyocytes. Biochem Biophys Res Commun 425:668-72 (2012). WB ; Mouse . PubMed: 22842467
  • Hassler MR  et al. Antineoplastic activity of the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine in anaplastic large cell lymphoma. Biochimie 94:2297-307 (2012). WB, IHC . PubMed: 22687603
  • Chik F & Szyf M Effects of specific DNMT gene depletion on cancer cell transformation and breast cancer cell invasion; toward selective DNMT inhibitors. Carcinogenesis 32:224-32 (2011). PubMed: 20980350
  • D'Aiuto L  et al. Mouse ES cells overexpressing DNMT1 produce abnormal neurons with upregulated NMDA/NR1 subunit. Differentiation 82:9-17 (2011). PubMed: 21492995
  • Negrotto S  et al. Noncytotoxic differentiation treatment of renal cell cancer. Cancer Res 71:1431-41 (2011). PubMed: 21303982
  • Leonard S  et al. Epigenetic and Transcriptional Changes Which Follow Epstein-Barr Virus Infection of Germinal Center B Cells and Their Relevance to the Pathogenesis of Hodgkin's Lymphoma. J Virol 85:9568-77 (2011). PubMed: 21752916
  • Alcazar O  et al. Epigenetic regulation by decitabine of melanoma differentiation in vitro and in vivo. Int J Cancer : (2011). PubMed: 21796622
  • Zhao Z  et al. Epigenetic alterations regulate estradiol-induced enhancement of memory consolidation. Proc Natl Acad Sci U S A : (2010). WB ; Mouse . PubMed: 20212170
  • Brunmeir R  et al. Epigenetic regulation of a murine retrotransposon by a dual histone modification mark. PLoS Genet 6:e1000927 (2010). WB ; Mouse . PubMed: 20442873
  • Pan W  et al. MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1. J Immunol 184:6773-81 (2010). WB ; Human . PubMed: 20483747
  • Qin T  et al. Mechanisms of resistance to 5-aza-2'-deoxycytidine in human cancer cell lines. Blood 113:659-67 (2009). WB ; Human . PubMed: 18931345
  • Fiskus W  et al. Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells. Blood 114:2733-43 (2009). WB ; Human . PubMed: 19638619
  • Yaqinuddin A  et al. DNMT1 silencing affects locus specific DNA methylation and increases prostate cancer derived PC3 cell invasiveness. J Urol 182:756-61 (2009). PubMed: 19539327
  • Li Q  et al. Three epigenetic drugs up-regulate homeobox gene Rhox5 in cancer cells through overlapping and distinct molecular mechanisms. Mol Pharmacol 76:1072-81 (2009). WB ; Human . PubMed: 19679824
  • Foltz G  et al. DNA methyltransferase-mediated transcriptional silencing in malignant glioma: a combined whole-genome microarray and promoter array analysis. Oncogene 28:2667-77 (2009). WB ; Human . PubMed: 19465937
  • Wu LP  et al. HDAC inhibitor depsipeptide activates silenced genes through decreasing both CpG and H3K9 methylation on the promoter. Mol Cell Biol : (2008). WB ; Human . PubMed: 18332107
  • Vincent A  et al. Epigenetic regulation of the human mucin gene MUC4 in epithelial cancer cell lines involves both DNA methylation and histone modifications mediated by DNA methyltransferases and histone deacetylases. FASEB J : (2008). PubMed: 18492726
  • Kiskinis E  et al. RIP140 directs histone and DNA methylation to silence Ucp1 expression in white adipocytes. EMBO J 26:4831-40 (2007). WB ; Human . PubMed: 17972916
  • Viré E  et al. The Polycomb group protein EZH2 directly controls DNA methylation. Nature : (2005). PubMed: 16357870

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up