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Neuroscience Neurotransmitter Amino Acids Glutamate
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DNQX disodium salt, AMPA / kainate antagonist (ab120169)

  • Datasheet
  • SDS
  • COA
Submit a review Q&A (1)References (10)

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Functional Studies - DNQX disodium salt, AMPA / kainate antagonist (ab120169)

    Key features and details

    • AMPA / kainate antagonist; water soluble
    • CAS Number:
    • Purity: > 99%
    • Soluble in water to 100 mM
    • Form / State: Solid
    • Source: Synthetic

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    Overview

    • Product name

      DNQX disodium salt, AMPA / kainate antagonist
    • Description

      AMPA / kainate antagonist; water soluble
    • Biological description

      Water soluble AMPA / kainate antagonist.

      Also available in simple stock solutions (ab144496) - add 1 ml of water to get an exact, ready-to-use concentration.

    • Purity

      > 99%
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      6,7-Dinitroquinoxaline-2,3-dione disodium salt
    • Molecular weight

      296.11
    • Molecular formula

      C8H2N4Na2O6
    • PubChem identifier

      45073428
    • Storage instructions

      Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
    • Solubility overview

      Soluble in water to 100 mM
    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      [Na+].[Na+].[O-][N+](=O)c1cc2nc([O-])c([O-])nc2cc1[N+]([O-])=O
    • Source

      Synthetic

    • Research areas

      • Neuroscience
      • Neurotransmitter
      • Amino Acids
      • Glutamate
      • Neuroscience
      • Neurotransmission
      • Receptors / Channels
      • GPCR
      • Glutamate Receptors
      • Neuroscience
      • Neurotransmission
      • Receptors / Channels
      • Ligand-Gated Ion Channels
      • AMPA / Kainate
      • Biochemicals
      • Product Range
      • Just Add Water
      • Biochemicals
      • Chemical Type
      • Biochemicals
      • Biochemicals
      • Pharmacology
      • Receptors & Transporters
      • Glutamate
      • AMPA & Kainate
      • Biochemicals
      • Pharmacology
      • Receptors & Transporters
      • Glutamate
      • AMPA & Kainate
      • Antagonists
      • Biochemicals
      • Research Area
      • Addiction
      • Glutamate
      • AMPA & Kainate
      • Biochemicals
      • Research Area
      • Addiction
      • Glutamate
      • AMPA & Kainate
      • Antagonists
      • Biochemicals
      • Research Area
      • Alzheimer's Disease
      • Glutamate
      • AMPA & Kainate
      • Biochemicals
      • Research Area
      • Alzheimer's Disease
      • Glutamate
      • AMPA & Kainate
      • Antagonists
      • Biochemicals
      • Research Area
      • Depression
      • Glutamate
      • AMPA & Kainate
      • Biochemicals
      • Research Area
      • Depression
      • Glutamate
      • AMPA & Kainate
      • Antagonists
      • Biochemicals
      • Research Area
      • Pain & inflammation
      • Glutamate
      • AMPA & Kainate
      • Biochemicals
      • Research Area
      • Pain & inflammation
      • Glutamate
      • AMPA & Kainate
      • Antagonists
      • Biochemicals
      • Research Area
      • Parkinson's Disease
      • Glutamate
      • AMPA & Kainate
      • Biochemicals
      • Research Area
      • Parkinson's Disease
      • Glutamate
      • AMPA & Kainate
      • Antagonists
      • Biochemicals
      • Research Area
      • Schizophrenia
      • Glutamate
      • AMPA & Kainate
      • Biochemicals
      • Research Area
      • Schizophrenia
      • Glutamate
      • AMPA & Kainate
      • Antagonists
      • Biochemicals
      • Research Area
      • Stroke
      • Glutamate
      • AMPA & Kainate
      • Biochemicals
      • Research Area
      • Stroke
      • Glutamate
      • AMPA & Kainate
      • Antagonists

    Associated products

      Applications

      The Abpromise guarantee

      Our Abpromise guarantee covers the use of ab120169 in the following tested applications.

      The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

      Application Abreviews Notes
      Functional Studies
      Use at an assay dependent concentration.
      Notes
      Functional Studies
      Use at an assay dependent concentration.

      Images

      • Functional Studies - DNQX disodium salt, AMPA / kainate antagonist (ab120169)
        Functional Studies - DNQX disodium salt, AMPA / kainate antagonist (ab120169)
        ab96379 staining MEK1 (phospho S298) in SK-N-SH cells treated with DNQX disodium salt (ab120169), by ICC/IF. Decrease in MEK1 (phospho S298) expression correlates with increased concentration of DNQX disodium salt, as described in literature.
        The cells were incubated at 37°C for 3h in media containing different concentrations of ab120169 (DNQX disodium salt) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab96379 (1/100 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody.

      Protocols

      To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

      Click here to view the general protocols

      Datasheets and documents

      • SDS download

      • Datasheet download

        Download
      • COA

      References (10)

      Publishing research using ab120169? Please let us know so that we can cite the reference in this datasheet.

      ab120169 has been referenced in 10 publications.

      • Raja MK  et al. Elevated synaptic vesicle release probability in synaptophysin/gyrin family quadruple knockouts. Elife 8:N/A (2019). PubMed: 31090538
      • McIver EL  et al. Maladaptive Downregulation of Autonomous Subthalamic Nucleus Activity following the Loss of Midbrain Dopamine Neurons. Cell Rep 28:992-1002.e4 (2019). PubMed: 31340159
      • Sahu G  et al. Junctophilin Proteins Tether a Cav1-RyR2-KCa3.1 Tripartite Complex to Regulate Neuronal Excitability. Cell Rep 28:2427-2442.e6 (2019). PubMed: 31461656
      • Chu HY  et al. Loss of Hyperdirect Pathway Cortico-Subthalamic Inputs Following Degeneration of Midbrain Dopamine Neurons. Neuron 95:1306-1318.e5 (2017). PubMed: 28910619
      • Kim CS & Johnston D A1 adenosine receptor-mediated GIRK channels contribute to the resting conductance of CA1 neurons in the dorsal hippocampus. J Neurophysiol 113:2511-23 (2015). PubMed: 25652929
      • Anderson CT  et al. Modulation of extrasynaptic NMDA receptors by synaptic and tonic zinc. Proc Natl Acad Sci U S A 112:E2705-14 (2015). PubMed: 25947151
      • Mlinar B  et al. Nonexocytotic serotonin release tonically suppresses serotonergic neuron activity. J Gen Physiol 145:225-51 (2015). PubMed: 25712017
      • Kyuyoung CL & Huguenard JR Modulation of short-term plasticity in the corticothalamic circuit by group III metabotropic glutamate receptors. J Neurosci 34:675-87 (2014). PubMed: 24403165
      • Saiepour MH  et al. Competition and Homeostasis of Excitatory and Inhibitory Connectivity in the Adult Mouse Visual Cortex. Cereb Cortex : (2014). PubMed: 25316336
      • Kasanetz F  et al. Transition to addiction is associated with a persistent impairment in synaptic plasticity. Science 328:1709-12 (2010). PubMed: 20576893

      Customer reviews and Q&As

      Show All Reviews Q&A
      Submit a review Submit a question

      Question

      Can you provide additional details on the conditions of RP-HPLC used to purify this product?

      Read More

      Abcam community

      Verified customer

      Asked on Aug 23 2012

      Answer

      Thank you for contacting Abcam and for your interest in our products.


      Regarding ab120044 and ab120169, we don't use HPLC to purify the product, it is used only to analyse it.Our methods of purification are proprietary. We would therefore need more clarification about the experiment you are conducting in order to provide further advice.


      Please do not hesitate to contact me if you have any additional questions.

      Read More

      Abcam Scientific Support

      Answered on Aug 23 2012

      Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
      For licensing inquiries, please contact partnerships@abcam.com

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