Docetaxel, Cytotoxic agent (ab141248)

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Overview

  • Product name

    Docetaxel, Cytotoxic agent

  • Description

    Potent cytotoxic agent

  • Biological description

    Potent cytotoxic agent in vitro (IC50 = 2 nM). Disrupts microtubule assembly and arrests cell divison at G2/M phase. Induces apoptosis. Antitumor agent. Active in vivo and in vitro.

  • Purity

    > 99%

  • CAS Number

    114977-28-5

  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (αR,βS)-β-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-hydroxybenzenepropanoic acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester

  • Molecular weight

    807.89

  • Molecular formula

    C43H53NO14

  • PubChem identifier

    148124

  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.

  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 100 mM

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(C)(C)OC(=O)N[C@@H](c1ccccc1)[C@@H](O)C(=O)O[C@H]5C[C@@]6(O)[C@@H](OC(=O)c2ccccc2)[C@H]3[C@@](C)([C@@H](O)C[C@H]4OC[C@@]34OC(C)=O)C(=O)[C@H](O)C(=C5C)C6(C)C

  • Source

    Synthetic

References

This product has been referenced in:

  • Fabbri F  et al. Mitotic catastrophe and apoptosis induced by docetaxel in hormone-refractory prostate cancer cells. J Cell Physiol 217:494-501 (2008). Read more (PubMed: 18615564) »
  • Schimming R  et al. Lack of correlation between mitotic arrest or apoptosis and antitumor effect of docetaxel. Cancer Chemother Pharmacol 43:165-72 (1999). Read more (PubMed: 9923824) »
  • Riccardi A  et al. Cytotoxicity of paclitaxel and docetaxel in human neuroblastoma cell lines. Eur J Cancer 31A:494-9 (1995). Read more (PubMed: 7576952) »
See 1 Publication for this product

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