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    docetaxel-cytotoxic-agent-ab141248.pdf

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Cell Biology Cell Cycle Cell Cycle Inhibitors p53
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Docetaxel, Cytotoxic agent (ab141248)

  • Datasheet
  • SDS
  • COA
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Chemical Structure - Docetaxel, Cytotoxic agent (ab141248)

    Key features and details

    • Potent cytotoxic agent
    • CAS Number: 114977-28-5
    • Purity: > 99%
    • Soluble in DMSO to 100 mM and in ethanol to 100 mM
    • Form / State: Solid
    • Source: Synthetic

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    Overview

    • Product name

      Docetaxel, Cytotoxic agent
    • Description

      Potent cytotoxic agent
    • Biological description

      Potent cytotoxic agent in vitro (IC50 = 2 nM). Disrupts microtubule assembly and arrests cell divison at G2/M phase. Induces apoptosis. Antitumor agent. Active in vivo and in vitro.

    • Purity

      > 99%
    • CAS Number

      114977-28-5
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      (αR,βS)-β-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-hydroxybenzenepropanoic acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester
    • Molecular weight

      807.89
    • Molecular formula

      C43H53NO14
    • PubChem identifier

      148124
    • Storage instructions

      Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
    • Solubility overview

      Soluble in DMSO to 100 mM and in ethanol to 100 mM
    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      CC(C)(C)OC(=O)N[C@@H](c1ccccc1)[C@@H](O)C(=O)O[C@H]5C[C@@]6(O)[C@@H](OC(=O)c2ccccc2)[C@H]3[C@@](C)([C@@H](O)C[C@H]4OC[C@@]34OC(C)=O)C(=O)[C@H](O)C(=C5C)C6(C)C
    • Source

      Synthetic

    • Research areas

      • Cell Biology
      • Cell Cycle
      • Cell Cycle Inhibitors
      • p53
      • Cell Biology
      • Apoptosis
      • Intracellular
      • p53 Pathway
      • Epigenetics and Nuclear Signaling
      • DNA / RNA
      • DNA Damage & Repair
      • DNA Damage Response
      • p53
      • Epigenetics and Nuclear Signaling
      • DNA / RNA
      • DNA Synthesis
      • Topoisomerases
      • Epigenetics and Nuclear Signaling
      • Transcription
      • Domain Families
      • Zinc Finger
      • Cell Biology
      • Apoptosis
      • Intracellular
      • Caspases etc
      • CARD Family
      • Signal Transduction
      • Signaling Pathway
      • Nuclear Signaling
      • Nuclear Hormone Receptors
      • Estrogen
      • Signal Transduction
      • Signaling Pathway
      • Nuclear Signaling
      • Nuclear Hormone Receptors
      • Corticoid
      • Signal Transduction
      • Signaling Pathway
      • Nuclear Signaling
      • Nuclear Hormone Receptors
      • Testosterone
      • Signal Transduction
      • Signaling Pathway
      • Nuclear Signaling
      • Nuclear Hormone Receptors
      • Retinoic & Retinoid
      • Signal Transduction
      • Metabolism
      • Plasma Membrane
      • Channels
      • Neuroscience
      • Endocrine system
      • Gonadotrophic axis
      • Epigenetics and Nuclear Signaling
      • Transcription
      • Cancer susceptibility
      • Tumor Suppressors
      • Epigenetics and Nuclear Signaling
      • Nuclear Signaling Pathways
      • Nuclear Receptors
      • Corticoid
      • Epigenetics and Nuclear Signaling
      • Nuclear Signaling Pathways
      • Nuclear Receptors
      • Estrogen
      • Epigenetics and Nuclear Signaling
      • Nuclear Signaling Pathways
      • Nuclear Receptors
      • Retinoic & Retinoid
      • Epigenetics and Nuclear Signaling
      • Nuclear Signaling Pathways
      • Nuclear Receptors
      • Testosterone
      • Epigenetics and Nuclear Signaling
      • Cell cycle
      • Cell Cycle Inhibitors
      • p53
      • Epigenetics and Nuclear Signaling
      • Nuclear Signaling Pathways
      • Nuclear Receptors
      • Orphan Nuclear Receptors
      • Signal Transduction
      • Metabolism
      • Lipid metabolism
      • Signal Transduction
      • Metabolism
      • Drug metabolism
      • Cancer
      • Cell cycle
      • Cell cycle inhibitors
      • p53 pathway
      • Cancer
      • Signal transduction
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      • Nuclear hormone receptors
      • Estrogen
      • Cancer
      • Signal transduction
      • Nuclear signaling
      • Nuclear hormone receptors
      • Retanoic and retanoid
      • Cancer
      • Signal transduction
      • Nuclear signaling
      • Nuclear hormone receptors
      • Other
      • Cancer
      • Oncoproteins/suppressors
      • Tumor suppressors
      • p53 pathway
      • Cancer
      • Tumor biomarkers
      • Receptors
      • Developmental Biology
      • Reproduction
      • Hormones
      • Cancer
      • Cancer Metabolism
      • Metabolic signaling pathway
      • Metabolism of lipids and lipoproteins
      • Metabolism
      • Pathways and Processes
      • Mitochondrial Metabolism
      • Mitochondrial Biogenesis
      • Metabolism
      • Pathways and Processes
      • Metabolic signaling pathways
      • Nucleotide metabolism
      • Molecular processes
      • Mitochondrial transcription
      • Metabolism
      • Pathways and Processes
      • Metabolic signaling pathways
      • Lipid and lipoprotein metabolism
      • Lipid metabolism
      • Metabolism
      • Pathways and Processes
      • Metabolic signaling pathways
      • Drug metabolism

    Images

    • Chemical Structure - Docetaxel, Cytotoxic agent (ab141248)
      Chemical Structure - Docetaxel, Cytotoxic agent (ab141248)
      2D chemical structure image of ab141248, Docetaxel, Cytotoxic agent

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download
    • COA

    References (2)

    Publishing research using ab141248? Please let us know so that we can cite the reference in this datasheet.

    ab141248 has been referenced in 2 publications.

    • Purba TS  et al. CDK4/6 inhibition mitigates stem cell damage in a novel model for taxane-induced alopecia. EMBO Mol Med 11:e11031 (2019). PubMed: 31512803
    • Zeng J  et al. PrLZ increases prostate cancer docetaxel resistance by inhibiting LKB1/AMPK-mediated autophagy. Theranostics 8:109-123 (2018). PubMed: 29290796

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